Effects Of Toltrazuril And Other Drugs On The Rex Rabbits’ Infection Of Coccidiosis And The Immature Rabbits’ Growth

Rabbit coccidiosis is widespread across the word,which occurs in immature rabbits mainly during the age of 1 to 3 month,with high incidence rate and high death rate,the rabbits resistanced to the parasite disease,becoming the source of infection,affecting the growth and development,and economic loss.Rex rabbit is a kind of typical rabbit with skin used,and rabbit coccidiosis’ damage is also very serious to the Rex rabbit.Toltrazuril is a kind of newer drug than other coccidiostats of rabbit,so we did the test that the effect of toltrazuril to the Rex rabbits.The main results as followed:1.In order to study coccidium infection of the Rex rabbit farm’s immature rabbits with weaned in Fuan,Fujian,238 weaned rabbits were collected to diagnose the coccidium infection and species of coccidium.The results showed that the total prevalence was 100%and the mean oocysts per gram(OPG)value was 4.98×104;16 species of Eimeria were identified from the survey,which were mixed infection with more than one species,E.perforans(16.23%),E.exigue(14.82%),E.nagpurensis(12.96%)and E.matsubayashii(11.66%)were dominant species.2.In order to study the effect of Toltrazuril and other drugs on the Rex rabbits coccidium infection,238 weaned rabbits were selected and divided into 9 groups randomly:2.5%toltrazuril,5%toltrazuril,5%amprolium hydrochloride and sulfaquioxaline sodium soluble powder and 5%decoquinate premix,which included one and twice treatment,and control group(physiological saline group).At the time of weaned and one week after weaned,fed with 2.5%toltrazuril and 5%toltrazuril by the dose of 30mg/kg,and Amprolium Hydrochloride and sulfaquioxaline Sodium Soluble Powder and Decoquinate Premix by the dose of 50mg/kg,and fed the control group’s rabbits with the saline 1mL.Collected the fecal samples to detect the occidiosis oocysts regularly.The results showed,the OPG values of 5%toltrazuril group were significantly less than that of other drug groups and control group at the time of one week after treatment(P<0.01),and the incidence rate(76.47%)was lowest than other groups.The OPG values of toltrazuril groups with twice treatment were also significantly less than that of other drug groups and control group at the time of the second week and the third week after treatment(P<0.01),and the incidence rate were lowest than other groups.The OPG values of 2.5%toltrazuril group with one time of treatment was significantly less than that of 5%toltrazuril group with twice treatment at the time of the eighth week after treatment(P<0.05).Studies indicated that,toltrazuril at the dose of 30 mg/kg can prevent the rabbits coccidiosis effectively,and it was better to the twice treatment.The effect of 5%toltrazuril was better than that of 2.5%toltrazuril.Besides,amprolium hydrochloride and sulfaquioxaline sodium soluble powder and decoquinate premix were not obvious to prevent the rabbits coccidiosis by the dose of 50 mg/kg.3.In order to study the effects of toltrazuril and other drugs on the infection of each species of the Rex coccidium,three kinds of anticoccidal drugs were selected to do the test.The coccidosis oocysts in the fecal samples of the coccidium were detected before treatment and the one week after treatment.The results showed that,16 species of Eimeria were identified from the survey in this rabbitry,the reduction of OPG values with E.nagpurensis,E.magnam,E.exigue,E.media,E.flavescens and E.elongata,which of 2.5%toltrazuril group were all significantly higher than that of control group(P<0.01).The reduction of OPG values with E.nagpurensis,E.perforans,E.magnam,E.exigue,E.stiedai and E.intestinalis,which of 5%toltrazuril group were significantly higher than that of other drug groups and control group(P<0.05),but with the reduction of OPG values of E.media.The reduction of OPG values with E.nagpurensis and E.perforans,which of Amprolium Hydrochloride and sulfaquioxaline Sodium Soluble Powder group were all significantly higher than that of control group(P<0.05).It was not detected the diference significantly between decoquinate premix group and control group(P>0.05).4.In order to study the effects of toltrazuril and other drugs on the immature rabbits’ growth,three kinds of anticoccidal drugs were selected to do the test.Weighed the rabbits’ body weight regularly at the time from weaned day to the eighth week after treatment,and under the analysis of variance and covariance.Results showed,the average weight of Rex rabbits were no significant difference between each groups before treatment(P>0.05).And also the average of weight increase with Rex rabbits was no significant difference between each groups after treatment(P>0.05).