Study On The Electrochemical Recognition Performance Of Polymers Containing Chiral Oxazoline Groups

Chiral enantiomer recognition is a special kind of chemical biological recognition,which has received more and more attention in the fields of chemistry and biology,and has become a hotspot of analysis and research at this stage.At present,a variety of analytical methods have successfully realized the chiral enantiomer recognition process,which makes us have a full understanding of chiral enantiomer recognition.The identification process and identification mechanism of different analytical methods are explored.These have important scientific significance and practical value for life process research,asymmetric synthesis,new drug development,and biological environment monitoring.In this paper,the new sensing interface of electrochemical analysis method was studied,and three effective chiral polymer recognition sensing systems were established.The different systems were prepared,characterized and analyzed,and the more meaningful research results were obtained.The main contents of this paper are as follows;(1)A new diynefluorene derivative monomer 1c with chiral oxazoline group was synthesized,it was copolymerized with 1,2-ethanedithiol in the presence of benzophenone,and then coordinated with Pd²⁺.A chiral polymer doped metal Pd²⁺composite Poly[(R)-DFSE]/Pd²⁺electrochemical sensor was constructed.An organic chiral film was formed on the surface of GCE for efficient response and selective recognition of tryptophan enantiomers.(2)The monomer 2c of malononitrile derivative with side chiral oxazoline group was synthesized,the non-conductive polymer chiral material Poly[(R)-TDPY]was synthesized by oxidative coupling polymerization with TMED-Cu Cl as catalyst.The electrochemical chiral sensing interface constructed by Poly[(R)-TDPY]has good recognition for propranolol enantiomers.(3)By adding acetylene black into Poly[(R)-TDPY]polymerization raw materials,Poly[(R)-TDPY]@AB composite material doped with acetylene black was generated in situ.The electrochemical characterization showed that the polymer performance was improved successfully,and the modified material had better recognition effect on the enantiomers of phenylglycine alcohol.