Design, Assembly And Performance Of Chiral Phenolic In - MOF

The field of Chiral Metal-Organic Frameworks(CMOFs) represents a burgeoning area with versatile applications in various aspects, such as heterogeneous catalysis,chiral recognition and separation, enantioselective sensor, et al. In this thesis, an axially C2-symmetric Biphenyl scaffold with carboxyl-functionalized organic linker was synthesized and further utilized to build chiral porous crystalline material with In3+. This material is well characterized by XRD, EA, IR, and TGA, etc. They were very stable and applied to chiral recognition and separation,chiral fluorescence, chiral induced crystallization. The thesis includes four chapters as follows:In the first chapter, the research process of CMOFs is briefly introduced, including their synthetic approaches and applications in heterogeneous catalysis, chiral recognition and separation as well as chiral sensor; then the significance and overview of the thesis were presented.In the second chapter, an axially C2-symmetric 1,1′-biphenol ligand H4 L was synthesized via nine steps and used to build a homochiral nanoporous(R)-In-MOF with In Cl3 through self-assembly. This material is well characterized by TGA, CD, PXRD, BET, etc.In the third chapter, the material(R)-In-MOF was demonstrated to be an excellent solid-state host to enantioselectively adsorb and separate aromatic sulfoxides derivatives(up to 97.7% ee). The host material can be readily recycled and reused without any apparent loss of enantioselectivity. The material(R)-In-MOF was demonstrated to be a chiral sensor with a number of chiral sugars(Ksv= 5.82±0.18);(R)-In-MOF was used to induce saturated alanine to produce chiral crystals as a chiral induced medium(up to 93% ee).In the fourth chapter, a brief conclusion and outlook of this thesis were made.