Synthesis Of Novel Glycopolymers Via Click Chemistry And Postpolymerization Modification And Their Specific Recognition Of Protein

Glycopolymers with side chain sugar motifs can mimic the biological functions of natural carbohydrates and produce multivalent interactions with lectins on cells,which have important applications in biomedical field.Moreover,the glycopolymers have a huge adjustable range in terms of the valency of sugar residues on the chain,the function of linker and the overall architecture,which has outstanding advantages for the systematic study of the influence of glycocluster structure on recognition performance.Accurate synthesis of hetero-or homoglycopolymers and the study of their recognition mechanism and influencing factors with lectins have always been the focus of research,which is of great significance for the development of new drugs and the application of biotechnology.The influence of structural characteristics of glycopolymers on their recognition performance with lectin was studied.The research includes the following two parts:(1)Synthesis of well-defined heteroglycopolymers via combining sequential click reactions and PPM: the effects of linker and heterogeneity on Con A binding;(2)Carbohydrate-lectin recongnition of well-defined heterogeneous dendronized homo/hetero(bi or trifunctional)glycopolymers: systematic studies on heterogenity in glycopolymers-lectin binding.In this paper,a library of well-defined homo and hetero-glycopolymers consisting of different sugar units in the side chain were generated by reacting poly(pentafluorophenyl acrylate)(p PFPA)with functionalized sugar amines via post-polymerization modification.Subsequently,the influence of the structural characteristics of a series of synthesized glycopolymers on its recognition performance with lectins was studied.