NR1D2 2 Beginning Regulation Molecule And Knowledge System In ARF6 Feedback-activated Subnetworks For Learning

The high expression ARF6 feedback-activated multiple subnetworks containing NR1D2₂ were constructed in human left brain from previously established GRNInfer molecular database.The corresponding common cellular location and tissue distribution were calculated based on previously identified DAVID,respectively.The following hypothesis was proposed and verified:1.From plasma membrane G protein-coupled receptor 68(GPR 68)to nuclear receptor subfamily 1 group D member 2(NR1D2₂)induced learning,including RFK subnetwork especially present in urinary bladder tumor|uterine tumor|soft tissue/muscle tissue tumor|ad renal tumor|ovarian tumor,and TERF1₁ subnetwork especially pres ent in heart|Whole Brain|Uterus Corpus|liver|retinoblastoma,and KIA A0888 subnetwork especially present in Myocytes|uterus|Prostate|App endix|Pons|adrenal gland|Olfactory Bulb.2.From plasma membrane somatostatin receptor 2(SSTR2)to nuclear receptor subfamily 1 group D member 2(NRID2₂)induce d learning,including PRKCI₁ subnetwork especially present in Te mporalLobe|Ciliary Ganglion|fetalbrain|Uterus Corpus|adipose tissue|H eart,and PDE4DIP knowledge subnetwork especially present in Tem poralLobe|skin tumor|soft tissue/muscle tissue tumor|fetalbrain|Pituitar y|adipose tissue|heart|adrenal tumor|ovarian tumor.3.Positive self-feedback nuclear receptor subfamily 1 group D member 2(NR1D2₂)induced learning,including SSTR2 subnetwor k especially present in Pituitary|non glioma|retinoblastoma|thyroid,an d GPR68 subnetwork especially present in uterine tumor.4.From mitochondrion riboflavin kinase(RFK)to nuclear rece ptor subfamily 1 group D member 2(NR1D2₂)induced learning,including BRP44 subnetwork especially present in adrenal gland.