Differential Expression of TWSG1, BMP4 and Shh Morphogens Signaling Proteins in Hepatocellular Carcinoma and Cholangiocellular Carcinoma | Posted on:2015-05-14 | Degree:M.S | Type:Thesis | University:University of Alberta (Canada) | Candidate:Albahrani, Redha Mohammed | Full Text:PDF | GTID:2474390017995854 | Subject:Medicine | Abstract/Summary: | | Hepatocellular carcinoma (HCC) and cholangiocellular carcinoma (CCA) constitute two of the most common liver malignancies in adults. The molecular mechanisms underlying their development remain poorly understood.;This thesis has demonstrated the differential expression and co-localization of the morphogen proteins, including sonic hedgehog (Shh), bone morphogenetic protein (BMP)-4 and twisted gastrulation protein (TWSG)-1 in human HCC and CCA tumors and cell lines. These proteins are strongly expressed in CCA more than in HCC.;Overall, these findings suggest that morphogen proteins may play a crucial role during liver carcinogenesis and progression, specifically in CCA. Moreover, these proteins can serve as diagnostic biomarkers for HCC and CCA.;Morphogen proteins, including the hedgehog and the bone morphogenetic proteins pathway fulfill a major role in embryonic development. Consequently, alterations in these proteins may cause embryonic defects. Furthermore, abnormal expression of morphogen proteins is found to correlate with cancer development and progression. | Keywords/Search Tags: | Proteins, Morphogen, CCA, Expression, Carcinoma, HCC | | Related items |
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