| Photodynamic therapy is a new approach to the treatment of human neoplasms. It involves a photosensitizer and light. The combination of these two results in tumor destruction. The photodynamic effect of SnET2 when combined with red light in vivo results in decreased tumor blood flow, hemorrage, and tumor cell necrosis. The specific aim of this study was to evaluate the effects of SnET2-PDT on blood vessels.; The rat aorta was examined 24 h after SnET-PDT. The results showed that the endothelial cell was affected by SnET2-PDT. The tumor blood flow was measured after HpD-PDT or SnET2-PDT with or without indomethacin. The tumor blood flow reduction after HpD-PDT or SnET2-PDT was inhibited by indomethacin. The 30 d tumor response study suggested that the laser is a better light source than a noncoherent light source. |
