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The caffeine breath test: A less invasive method to measure cytochrome P450-1A activity in birds

Posted on:1995-02-11Degree:M.SType:Thesis
University:Michigan State UniversityCandidate:Feyk, Lori AnnFull Text:PDF
GTID:2474390014990981Subject:Health Sciences
Abstract/Summary:
ytochrome P450-1A activity is often used as a biomarker of exposure of wildlife to planar polychlorinated diaromatic hydrocarbons, and is usually measured ex vivo in liver tissue. The purpose of this study was to develop a less invasive breath test to measure P450-1A activity in birds. This would allow an assessment of P450-1A activity without the need to kill birds, and would allow measurement on the same individual over time. Caffeine is specifically metabolized by P450-1A. The caffeine breath test (CBT) was performed by injecting...
Keywords/Search Tags:P450-1A, Caffeine breath test, Less invasive
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