Characterization of cytochrome P450-1A (CYP1A) enzymes in three avian species and the development of a caffeine breath test to measure CYP1A activity in vivo

Posted on:1998-10-17

Degree:Ph.D

Type:Dissertation

University:Michigan State University

Candidate:Feyk, Lori Ann

Full Text:PDF

GTID:1464390014976202

Subject:Health Sciences

Abstract/Summary:

Cytochrome P450-1A (CYP1A) activity is often used as a biomarker of exposure of wildlife to polyhalogenated diaromatic hydrocarbons (PHDHs), and is usually measured ex vivo in liver tissue. A caffeine breath test with radiolabelled substrate (;Thirty Common Tern (Sterna hirundu) hatchlings were fed fish containing PCB 126 and 2,2;Catalytic and immunochemical properties of avian hepatic microsomal CYP1A enzymes were characterized following treatment with ;...

Keywords/Search Tags:

Cytochrome P450-1A, Caffeine breath test

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