| The goals of this research include the development and evaluation of a technique for the determination of 3D orientations and positions of known objects from single-plane projection images, and the implementation of this technique for particular clinical applications.;The specific objectives include (1) the development and evaluation of a technique for the determination of the 3D orientations and positions of known objects, (2) the development and evaluation of a technique for calculation of biplane imaging geometries, providing the basis for 3D reconstructions of objects from biplane, and (3) the development and evaluation of techniques which provide the basis for the automated determination and visualization of the 3D orientations of catheters during interventional procedures.;The main hypothesis to be tested is that, given a single image of an object of known configuration and scale, the 3D orientation and position of the object can be determined accurately, precisely, and quickly.;This research is novel in that the 3D orientations and positions of objects as thin as catheters may be determined from a single projection image. This research is significant in that it has a broad range of clinical applications beyond those investigated specifically in this research. For example, the 3D information provided by the techniques developed in this research may be used to facilitate qualititative and quantitative evaluations of patients with applications to diagnostic procedures. In addition, the techniques developed in this research may be used to facilitate the registration and fusion of patient data acquired using multiple imaging modalities with applications to radiotherapy treatment planning as well as to surgical planning and guidance. Thus, the techniques developed in this research may provide the basis for the more complete generation and integration of 3D information into various clinical procedures. |
