| Neural engineering is a growing field with many clinical and scientific applications. Using the sea slug Aplysia californica as a model nervous system, this thesis details the development of technology for neural recording and stimulation. It first explores the theoretical basis of electrode interaction with the neurons using a mathematical model and neural simulation software. Results include an electrode placement window of 160 mum for specific stimulation and techniques for multi-neuron activation in vivo. The thesis then details the development of two prototypes: a discrete component unit for multi-channel wireless neural recording, and an integrated device for neural stimulation, fabricated by MOSIS. The recording unit is capable of obtaining neural signals with noise down to 2.8 muVrms and transmitting through 18 cm of saltwater. The stimulation device successfully provides digitally controlled current up to +/-500 muA. Using the model and prototypes, design specifications are established for a complete multi-channel invertebrate neural interface. |
