| We have shown that a mixture of CLA isomers improves oral glucose tolerance and reduces glomerular hypertrophy in the kidneys of obese insulin-resistant fa/fa Zucker rats. Therefore, to investigate which CLA isomer is responsible for these effects, 6 week old male fa/fa Zucker rats and lean controls were given diets supplemented with either 0.4% (4 g/Kg) of the c9, t11 CLA isomer (designated as 9,11), 0.4% of the t10, c12 CLA isomer (designated as 10,12), a combination of the two isomers (0.4% c9, t11 and 0.4% t10, c12, designated as TOG) or control (0% CLA, designated as CTL) diet for 8 weeks. The fa/fa rats on the 10,12 diet ate significantly less than fa/fa rats on all other diets, but diet did not have a significant effect on final body weight. The fa/fa rats on the 10,12 diet had a significantly lower kidney weight than fa/fa rats on the CTL diet. (Abstract shortened by UMI.)... |
