| Existing microfluidic-based CE analysis systems require large external power supplies, relays and optics. This reliance limits the development of monolithic electronic-microfluidic-optical systems, which could form the basis of inexpensive hand-held point-of-care medical devices and miniaturized genetic testing platforms. In this work, we have developed several generations of high-voltage (HV) CMOS integrated circuits to replace this external infrastructure, integrating all electronics and optical detectors on a single HV CMOS substrate, offering for the first time the ability to reduce size and cost of existing systems through significantly improved integration. We demonstrate 5 V to 150 V conversion using a DC-DC boost converter (with 60 muA current source capability) and a picowatt sensitive integrated photodiode and transimpedance amplifier (TIA) circuit. In conjunction, a successive approximation ADC accurately digitizes outputs of the TIA, and a serial peripheral interface is used to communicate with a PC. We also propose and implement additional methods of optical detection and alternative circuits for low-power HV level-shifters. |
