| Purpose: The purpose of this study was to compare the effects of ibuprofen, a conventional NSAID, and celebrex, a COX-2 specific inhibitor, on tooth movement and root resorption. Methods: 49 female wistar rats were placed into 5 groups: (1) control (no dosage), (2) high dose celebrex (80mg/kg body weight), (3) high dose ibuprofen (50 mg/kg), (4) low dose celebrex (40 mg/kg), and (5) low dose ibuprofen (25 mg/kg). Rats were anesthetized by IP injection of Phenobarbital (0.1 mg/gm body weight), and a force of 80 grams was applied to the maxillary left first molars using a nickel titanium closed-coil spring. Tissue samples analyzed by light microscopy, and areas of resorption were quantified. Results: Ibuprofen and celebrex reduced resorption compared to control. High dose celebrex caused a reduction of tooth movement. Conclusions: There is minimal advantage in using selective COX-2 inhibitors to limit resorption; however, treatment time may be lengthened. |
