Research On The Distribution Of Syndrome Types And Characteristics Of Syndromes In Early And Mid-stage Parkinson's Disease

Objective: by studying the early metaphase evidence type distribution of Parkinson's disease and syndrome characteristics,at the same time observation of traditional Chinese medicine treatment of early metaphase comprehensive clinical curative effect of Parkinson's disease and Parkinson's disease rating scale UPDRS score comparison before and after the treatment,hope to be able to further for middle of traditional Chinese medicine treatment of Parkinson's disease to provide important basis for clinical promotion.Methods: 1)patients with early and middle stage Parkinson's disease who met the inclusion criteria were collected through multi-center outpatient service,and questionnaires were conducted to identify TCM syndromes and related contents.2)112 cases of early and middle stage Parkinson's disease were randomly divided into treatment group and control group with 56 cases each.The treatment group was given pingzhan prescription plus or minus according to the syndrome type in the conventional western medicine treatment,while the control group was given simulated traditional Chinese medicine granules in the conventional western medicine treatment for 24 weeks.The clinical efficacy of the two groups and the total UPDRS score before and after treatment were compared.Results: 1)there were 126 cases(40.9%)with liver and kidney deficiency syndrome,90 cases(29.2%)with qi and blood deficiency syndrome,48 cases(15.6%)with qi stagnation and blood stasis syndrome,and 44 cases(14.3%)with phlegm,heat and wind syndrome.There were no statistically significant differences in gender,age,course of disease,modified hoehn-yahr grading,motor symptoms(quiescent tremor,myotonia)between syndromes.Patients with phlegm,heat,and wind syndrome had the highest UPDRS scores,followed by those with insufficient qi and blood or liver and kidney syndrome,and those with qi stagnation and blood stasis syndrome had the lowest scores.Four types of syndrome types in there is no statistical difference of UPDRS ? score comparison,are statistically significant.Non-motor symptoms with rapid eye movement phase sleep behavior abnormal symptoms in liver and kidney deficiency and insufficient qi and blood syndrome.Accompany constipation symptom to see more at liver kidney inadequacy,qi and blood inadequacy and phlegm heat move wind syndrome.There was no statistical difference between the four types of depression symptoms.2)TCM syndrome differentiation has a significant effect on the treatment of early and middle stage Parkinson's disease,which is better than the previous single use of the old diping fibrillation prescription,and can effectively reduce the total UPDRS score.Conclusion: in early and middle stage of pd,liver and kidney insufficiency is the main type,and deficiency syndrome is the main type.Liver and kidney insufficiency runs through the early and middle stage of pd.The UPDRS score of phlegm,heat and wind syndrome was the highest,and the qi stagnation and blood stasis syndrome was the lowest.Patients with abnormal sleep behavior during rem sleep are more likely to have insufficient liver and kidney and insufficient qi and blood.The patient that accompanies constipation symptom sees at liver kidney inadequacy more,qi blood inadequacy and phlegm heat move wind syndrome.Clinical trials have found that TCM syndrome differentiation has a significant effect on the treatment of early and middle stage Parkinson's disease,which is superior to the previous single use of the ripe diping fibrillation prescription,and at the same time effectively reduces the total score of UPDRS.It further proves that the study of early and middle stage of Parkinson's disease syndrome differentiation has clinical practical significance.