Research On The Correlation Between NAFLD And Its TCM Syndromes, Inflammatory Factors And SCD36

ObjectiveTo explore the characteristics of non-alcoholic fatty liver disease(NAFLD)biochemical indexes,inflammatory factors and serum cluster of differentiation 36(sCD36)in different Traditional Chinese Medicine(TCM)syndromes and severityMethodsSubjects were randomly recruited in the Physical Examination Center of the China-Japan Friendship Hospital from October 2018 to April 2019.The subjects were divided into NAFLD groups(mild group,moderate group and severe group)and control group according to MRI-proton density fat fraction(PDFF).Collected the general clinical data and detected the serum biochemical indexes,inflammatory factors and sCD36.NAFLD patients were classified by TCM syndrome differentiation.Database was established by the clinical data information system of the China-Japan Friendship Hospital and exported as an excel table.The data was statistically analyzed by SPSS22.0 software.Results1.Comparison between control group and NAFLD groups:130 subjects were enrolled,including 35 in the control group,48 in the NAFLD mild group,25 in the NAFLD moderate group and 22 in the NAFLD severe group.?Gender and age:the NAFLD groups' gender ratios were significantly higher than control group(P<0.01).The ages of the mild and moderate groups were significantly higher than healthy and severe groups(P<0.01).?Waist Circumference(WC),Waist-to-Hip Ratio(WHR),Body Mass Index(BMI):The levels of WC,WHR,BMI of NAFLD groups were significantly higher than control group(P<0.01).The WC of moderate and severe groups were significantly higher than mild group(P<0.05),the WHR of severe group was significantly higher than mild group(P<0.05),and the BMI of severe group was significantly higher than mild group(P<0.01).? Biochemical indexes:The levels of ALT,AST,TG,UA,GLU of NAFLD groups were significantly higher than those of control group(P<0.05).The ALT and AST levels in severe group were significantly higher than mild and moderate groups(P<0.05),the LDL-C levels in mild and moderate groups were significantly higher than control group(P<0.05),and the UA levels in the severe group were significantly higher than mild group(P<0.01).The abnormal rate of ALT and TG in NAFLD groups were significantly higher than control group(P<0.05),the abnormal rate of ALT of severe group was significantly higher than mild and moderate groups(P<0.01),the abnormal rate of AST of severe group significantly higher than control group(P<0.01),the abnormal rate of UA of severe group significantly higher than healthy and mild groups(P<0.05).There was no significant difference in the abnormal rates of TC and GLU in each group(P>0.05).2.Comparison of different TCM Syndromes of NAFLD:there are 95 cases of NAFLD patients,including 16 cases of liver-stagnation and spleen-deficiency syndrome(A group),45 cases of damp heat retention syndrome(B group),18 cases of phlegm-stasis cementation syndrome(C group),16 cases of phlegm stasis syndrome(D group).?In the symptom investigation,the top 10 symptoms with the highest frequency were as follows:sticky stool,halitosis,dry mouth.irritability,dry eyes,sore back and knees,urine yellow,mouth-bitterness,sweating and fatigue.?the age of C group was higher than that other groups(P<0.05);the gender composition of B group was significantly different from that of C group(35/10 vs 7/1 1),P<0.01.?the WC and BMI of A group were lower than other groups(P<0.05).The WC?BMI of D group were higher than B group(P<0.05).?There was no significant difference in liver function,blood lipid,uric acid,blood glucose levels and their abnormal rates among NAFLD TCM syndrome groups(P>0.05).3.Correlation analysis of inflammatory factors and sCD36 with clinical indexes and TCM syndrome types of NAFLD:88 serum samples were detected,including 26 in control group and 62 in NAFLD group.? There is a positive correlation between sCD36 and HS-CRP(P<0.05).?The level of IL-1 ? in the heat syndrome group was higher than that in the non-heat syndrome group(P<0.05).Conclusion1.The degree of hepatic steatosis of NAFLD is closely related to abdominal obesity,BMI,abnormal liver function and abnormal glucose and lipid metabolism.2.The damp heat retention syndrome is the most common type of NAFLD.The serum level of IL-1? in the heat syndrome group increased,indicating IL-1? may be the material basis for the formation of TCM heat syndrome.