| Objective:Treatise on Febrile Diseases has a definite curative effect,is well-organized,and has a wide range of clinical applications.In this paper,the relationship between "formulas-drug-syndrome"in Treatise on Febrile Diseases is theoretically discussed and data analysis is conducted.It is hoped that the exact curative effect of Jingfang can deepen the theoretical research on the compatibility of formulas and provide ideas and inspiration.Method:Using the method of literature collation and analysis,the data of the complete Chinese formulas of Treatise on Febrile Diseases is sorted out,the information of symptoms and formulas is extracted,and the formulas-syndrome relationship among them is combed and analyzed in literature,and part of the medicine-symptoms application Apriori algorithm of association rules,mining and analysis,combined with the textual analysis of the literature,to explore the "formulas-herb-syndrome" relationship of Treatise on Febrile Diseases,and finally to verify and analyze the relationship of "formulas-herb-syndrome" with medical records.Result:After the standardization,a total of 112 formulas,83 herbs,and 224 symptoms were included in the analysis.Formulas:Perform formulas-related analysis on formulas with a frequency of symptoms greater than or equal to 10 times,and analyze the every formula one by one.A total of 19 formulas were included in the analysis,namely Xiaochaihu Decoction,Dachengqi Decoction,Sini Decoction,Guizhi Decoction,Wuling Powder,Mahuang Decoction,Xiaochengqi Decoction,Gardenia Soup,Baihu Plus Ginseng Decoction,Dacai Chest soup,Dangdang soup,Tiaowei Chengqi soup,Tongmai Sini soup,Zhenwu soup,Xiaoqinglong soup,Baihu soup,Guadisan,Zhuling soup,Shizao soup.Herbs:The top 15 medicines and frequencies in the book Treatise on Febrile Diseases are:69 times of licorice,39 times of Guizhi,38 times of jujube,36 times of ginger,29 times of peony,21 times of dried ginger,20 times of ginseng,19 aconite 18 times,Pinellia 18 times,skullcap 17 times,rhubarb 15 times,ephedra 14 times,Coptis 13 times,Atractylodes 10 times,Poria 10 times.Symptoms:The top 5 symptoms in the book "Treatise on Febrile Diseases" are:Xili,fever,annoyance,cold hands and feet,and vomiting.Herb-symptoms:Set a minimum support of 10%and a minimum confidence of 10%,and analyze the association rules between symptoms and drugs for the top five symptoms.Diarrhea,in single flavor medicines,the percentages of diarrhea with licorice,twig,jujube,ginger,peony respectively are 63.303,35.780,34.862,33.028,26.606,Scutellaria,dried ginger,Coptis chinensis,Pinellia,ginseng The confidence percentages are 64.706,57.143,46.154,38.889,and 35.000,respectively.Herb pairs:Guizhi+licorice,jujube+licorice,ginger+jujube,peony+licorice,peony+jujube and the percentage of support of 33.028,28.440,28.440,22.018,18.349,Scutellaria+licorice,dried Ginger+licorice,Pinellia+jujube,Pinellia+licorice,ginseng+licorice have confidence percentages of 75.000,57.143,50.000,42.857,33.333+the herb group:ginger+jujube+licorice,peony+Guizhi+licorice,Paeonia lactiflora+ginger+jujube and diarrhea support percentage is 25.688,16.514,16.514.According to the difference between cold and heat,there are 6 formulas used by Reli and 37 times of herb using.Scutellaria,jujube and licorice are used more frequently,and the frequency is 4 times.The total frequency of use is 28 times,and the most used are dried ginger,licorice and aconite,the frequency is 6,4,3,there are 5 prescriptions for cold and heat,and the total use frequency is 27 times.Licorice,Coptis chinensis,Radix Scutellariae,Jujube,Pinellia,Ginseng,the frequency is 4,4,3,3,3,3.Fever:single medicine,ephedra,rhubarb,peony,ginger,dried ginger and fever with confidence percentages of 38.462,36.842,30.000,28.571,27.778,26.667,and support with licorice,twig,jujube,ginger,peony The percentages of degrees are 63.303,35.780,34.862,33.028,26.606;Herb pairs:Guizhi+licorice,ginger+jujube,ginger+licorice,Guizhi+ginger,peony+ginger and fever support percentages are 33.028,28.440,respectively,28.440,21.101,17.431,ephedra+licorice,peony+ginger,peony+jujube,dried ginger+licorice,peony+Guizhi,ginseng+licorice and fever confidence are 38.462,36.842,30.000,28.571,27.778,Heerb group:fever and peony+ginger+jujube,peony+ginger+licorice,peony+ guizhi+licorice,peony+ guizhi+ginger,peony+jujube+licorice,the confidence percentages are 33.333,29.412,27.778,26.667,26.316,fever and ginger+jujube+licorice,twig+jujube+licorice,twig+ginger+licorice,twig+ginger+jujube,peony +jujube+licorice support percentage of 25.688,21.101,20.183,19.26 6.16.514;Herb group:fever and peony+ginger+jujube+licorice,peony+Guizhi+ginger+jujube,peony+guizhi+ ginger+licorice,Guizhi+ginger+jujube+licorice,peony+Gui The confidence percentages of sticks+ jujube+licorice were 29.412,26.667,26.667,25.000 and 25.000,respectively.According to the difference of the six classics,there are 13 prescriptions for solar fever,and the frequency of herb using is 63.The most used herbs are Guizhi,licorice,peony,ginger,jujube,ephedra,and almond,with frequencies of 7,7,6,6,5,5,3,Shaoyang fever 3 formulas,the herb frequency is 24,the most used herbs are Bupleurum,baicalin,Pinellia,jujube,peony,licorice,ginseng,the frequency is 3,3,3,3,2,2,2,There are 6 formulas for Yangming fever,the herb frequency is 24,the most used herbs are rhubarb,licorice,Glauber's salt,ginseng;,Zhimu,Zhishi,the frequency is 3,3.2,2,2.Irritability:In the single-flavor medicine,the anomaly support percentages of licorice,twig,jujube,ginger,and peony are 63.303,35.780,34.862,33.028,and 26.606 respectively.The confidence percentages are 35.294,33.333,23.810,23.077,and 22.222;the herb pairs:Guizhi+ licorice,jujube+licorice,ginger+licorice,ginger+jujube,and the support percentages are 33.028,31.193,28.440,28.440,Irritability and Pinellia+jujube,skullcap+licorice,ginger+jujube confidence percentages are 33.333,25.000,19.355,the herb group:Irritability and peony+ginger+jujube,ginger+jujube+licorice,Gui The confidence and support of Zhi+Ginger+Jujube ranked top;the herb group:Irritability and Shaoyao+Guizhi+Ginger+Jujube,Peony+Guizhi+Ginger+Licorice had a confidence of 13.333,respectively.According to the etiology and pathogenesis of trouble,there are 8 prescriptions for real irritability,the frequency of drugs is 32,and the most used drugs are licorice,scutellaria,pinellia,jujube,dried ginger and ginseng,the frequencies are 5,2,and 2 respectively2,2,2,and 2,there are 5 prescriptions for deficiency and anxiety,the frequency of the drug is 17,and the most used drugs are licorice,dried ginger and peony,and the frequencies are 3,2,and 2.Hand-foot cold:In a single medicine,the support percentages of hand-foot cold and licorice,twig,jujube,ginger,peony are 63.303,35.780,34.862,33.028,26.606,hand-foot Jueleng and dried ginger,aconite,ginseng,Paeonia lactiflora,Licorice confidence percentages are 33.333,31.579,25.000,17.241,15.942;drug pairs:dried ginger+licorice,aconite+licorice,peony+licorice,peony+guizhi,scutellaria+licorice and hand foot cold,The degree percentages are 35.714,27.273,16.667,16.667,16.667,and the support percentages of Guizhi+licorice,peony+ licorice and hand,foot cold are 33.028 and 22.018,respectively.There are different hand,foot cold in Liujing disease.There are 2 Shao Yin hand and foot cold formulas.The herb frequency is 8,and the herbs are Evodia,ginseng,gingerjujube,Bupleurum,licorice,paeonia lactiflora,Zhishi,Juyin hand and foot cold.There are 4 formulas,and the frequency of herb use is 30.The most used herbs are licorice,guizhi,asarum,aconite,dried ginger,peony,and jujube,with frequencies of 3,3,3,2,2,2,respectively.,2.Vomiting:single medicine,the support percentages of Guizhi,jujube,ginger,peony and vomiting are 35.780,34.862,33.028,26.606;the confidence percentages of ginseng,skullcap,pinellia,dried ginger,ginger and vomiting are respectively 30.000,29.412,27.778,23.810,19.444,herb pairs:jujube+licorice,ginger+licorice,ginger+ jujube and vomiting support percentages are 31.143,28.440,28.440,pinellia+jujube,pinellia+licorice,Scutellaria root+licorice,ginseng+licorice,ginger+jujube and vomiting confidence percentages are 41.667,28.571,25.000,20.000,19.355;the herb group:ginger+jujube+licorice,peony+Guizhi+ginger and vomiting The confidence percentages were 14.286 and 13.333 respectively;the medicine group:peony+Guizhi+ginger+jujube,peony+ Guizhi+ginger+licorice and vomiting,the confidence percentages were 13.333 and 13.333,respectively.The pathogenesis of the six menstruation is different,the use of herbs is different,the sun vomiting formulas is 8,the frequency of the herb is 41,the herbs used more are licorice,jujube,Guizhi,peony,pinellia,dried ginger,ginger,The frequency of ephedra is 5,4,4,3,3,3,2,and 2,respectively.There are 3 Shaoyang vomiting formulas,the herb frequency is 24,the most used herbs are Bupleurum,Radix Scutellariae,Pinellia,Ginger,Jujube,Ginseng,Paeonia lactiflora.2.There are 4 formulas for Shaoyin vomiting,the frequency of the herb is 18,the most used ones are aconite,dried ginger and poria,the frequency is 3,2,2 and there are 2 formulas for vomiting Yin and the frequency of the herb is 14,Dried ginger,Coptis chinensis,and ginseng are mostly used,with a frequency of 2.Conclusion:In this article,on the basis of the complete articles and the database of the formulas of Treatise on Febrile Diseases,we use a combination of literature research and data mining techniques to explore the association between formulas and symptoms.Conclusions as followed:For formulas-symptoms:The treatment of seizing the "syndrome" and "pathogenesis" is the main key to the flexible application and addition and subtraction of the Zhongjing formulas in different clinical diseases,which is also the key to the formulas of the Chinese medicine in this study.If there is probable evidence,there are many clinical symptoms,you must start with the "key symptoms".Herb-symptoms:Scutellaria,dried ginger,Coptis chinensis,Pinellia,ginseng,licorice,twig,jujube,ginger and other herbs can be selected when diarrhea appears.Doctors can see the benefits of coldness clinically,and can be compatible with dried ginger,ginseng,licorice and jujube.See heat gains,good effect of compatibility with Scutellaria and Coptis.The combination of fever is similar to Guizhi Decoction,and the overall pathogenesis of fever is loss of yin and yang.Taiyang fever is commonly used sweat method,Yangming fever is generally used the following method,Shaoyang fever is used and method,Shaoyin fever method is warm,Jueyin fever is mainly used in combination with cold temperature,and both expel the excessive fluiid and blood stasis.The method of relieving dampness and dissipating blood stasis should be treated clinically according to the symptoms.The herbs for treating troubles are roughly consistent with Xiaochaihu and Xiaojianzhong Decoction.For real irritability,Xiaochaihu Decoction is mostly used,and for virtual irritability,Xiaojianzhong Decoction is mostly used.The selected herbs for hand,foot,cold are basically consistent with the components of Sini Decoction,Tongmai Sini Decoction,and Tongmai Sini Pig Bile Decoction.However,Yangming Jueni is oweing to heat and needs to be cleared.The main herbs are gypsum and Zhimu.The vomiting treatment herb combination is similar to the dried turmeric scutellaria huanglian ginseng soup,but the pathogenesis of vomiting is different,and the medication should be adjusted accordingly.The results of the study show that the top five most frequently occurring herbs in the book Treatise on Febrile Diseases happen to be the herb composition of Guizhi Decoction,and the symptoms of Guizhi Decoction also appear more frequently in the symptom-herb relationship.Therefore,taking Guizhi Decoction as a representative formulas for the combined research of"Formulas-herb-syndrome",the modern famous Chinese medical records of Guizhi Decoction were collected to conduct in-depth analysis from the aspects of treatment of diseases,main symptoms,special symptoms,and basic dosage.The conclusion is that Guizhi Decoction has a wide range of diseases,not only for colds,sweating,and fever,but also for dolphins,vomiting,and eye diseases.The symptoms involve a wide range,but sweating,fever,Bad wind,body pain,and fatigue are the main symptoms;the typical pulse is floating veins,the tongue is light tongue,thin white fur;modern dosage is 10g of Guizhi,10g of white peony root,6g of licorice,9g of ginger,12 pieces of jujube,and The dosages used in Treatise on Febrile Diseases are quite different,but the dosage of jujube is the same as that of Zhongjing.Consider the combined effects of natural,social,and policy factors.This research provides reference for the in-depth understanding of the compatibility laws and medication ideas of Treatise on Febrile Diseases by referring to the "Formulas-herb-syndrome" relationship,and at the same time provides a basis for achieving accurate clinical syndrome differentiation. |
PDF Full Text Request