| The incidence of pulmonary fibrosis in the clinic is increasing year by year,but there is no good treatment and drugs.Pulmonary fibrosis not only accumulates the interstitial lung,but also invades the air cavity structure of the alveoli,causing the alveolar fusion to form the lungs.Big bubble.In the late stage,the extracellular matrix is precipitated,and the airway is accumulated,and finally the honeycomb-like lung tissue is formed,and the function of the lung is substantially lost.Pulmonary fibrosis is currently not a good treatment and treatment,and it is one of the difficult diseases of WHO.It involves a wide variety of diseases(more than 140 kinds),most diseases(more than 65)are unknown,and the pathogenesis is not clear.Clear,and the onset is hidden.With the deepening of research and the deepening of related work,more and more confusion,Western medicine in the clinical use of hormones,immunosuppressive agents for the treatment of pulmonary fibrosis,the effect is not very good,and then some scholars from the Chinese medicine to find a solution,the ancients The record of pulmonary fibrosis is not very clear.There are related knowledge such as “lung sputum” and “lung sputum”.There are different opinions and different opinions.Without a unified understanding,the experience of the ancients cannot be passed down,let alone form a unified treatment method and Thinking,there is an urgent need to name the lung fibrosis,and then explore a new treatment path for treating lung fiber from Chinese medicine.This study aimed to explore the "recognition" of traditional Chinese medicine for pulmonary fibrosis.A cross-sectional study was conducted to collect the symptoms of patients with pulmonary fibrosis and to evaluate the severity of the symptoms.The main symptoms and main syndromes of patients with pulmonary fibrosis were analyzed to obtain pulmonary fibrosis.The most suitable for "pulmonary sputum",and the main pathogenesis of qi deficiency,yang deficiency,can also express the performance of qi deficiency,yin deficiency,suggesting that we should always consider the pathogenesis of qi deficiency when treating pulmonary fibrosis in the clinic.It has been found in the clinic that certain drugs may cause pulmonary fibrosis,which in turn creates an animal model of pulmonary fibrosis to study the mechanism and case characteristics of pulmonary fibrosis,but 200 drugs screened by existing models of pulmonary fibrosis.The corresponding effects have not been achieved,and the existing models have their own advantages and disadvantages,and do not mimic the characteristics of human pulmonary fibrosis.The author's instructor accidentally using large doses of grape seed extract in the clinic can cause pulmonary fibrosis,so explore whether high-dose grape seed extract can be used to make an animal model of pulmonary fibrosis.After daily administration of low,medium and high doses of grape seed extract to mice,the lungs of the mice were found to have fibrosis after one month,suggesting that grape seed extract can cause lung fiber in mice.Chemical.Furthermore,the activity of SOD in the lungs of mice,the determination of MDA content,and the level of gene expression of TGF-?1,COX-1 and COX-2 were measured to investigate the mechanism of grape seed extract-induced pulmonary fibrosis.It is concluded that grape seed extract interferes with the oxidation reaction of cells,interferes with the function of mitochondria,leads to apoptosis,causes inflammation of the body,a large amount of COX-2 is expressed,and releases TGF-?1 cell growth factor,leading to alveolar epithelial cells.Transformation into fibroblasts leads to collagen deposition and proliferation of connective tissue,leading to pulmonary fibrosis.According to the research of clinical cross-section,the patients with pulmonary fibrosis mainly showed qi deficiency and yang deficiency,and the patients with pulmonary fibrosis were mainly treated with asthma syndrome.Therefore,the new model was treated with Zhenwu Decoction and Zhigancao Decoction.Evaluate its therapeutic effect. |
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