A Clinical Study On Huhusan Combined With GnRHa To Inhibit The Recurrence Of Endometriosis After Surgery

Objective:To investigate the clinical efficacy of Hu-po san and GnRHa in inhibiting postoperative recurrence of endometriosis.Methods:To collect the 60 pelvic endometriosis patients diagnosed after laparoscopic or open conservative surgery by pathology in The Third Affiliated Hospital of Beijing University of Chinese Medicine from January 2017 to January 2018,postoperative 30 patients assisted with Hu-po san and GnRHa were considered as the study group,and another postoperative 30 patients who were injected with GnRHa alone were used as the control group,then compare the two groups of patients separately,including postoperative recurrence rate、clinical symptoms、Immune indicators、CA125 and six sex hormones to observe the improvements the before and after medication.Results:This study takes fifty-four cases as research objects who complete treament duration and were followed up to stop taking medicine for nine months,including fifty-four patients in the observation group and the treatment group respectively.1.Compared with the GnRHa and Chinese medicine group,the average diameter of recurrent cyst was higher than the GnRHa group after nine months without taking medicine,and the difference was statistically significant.2.Compared with the postoperation,the levels of CA125 of the two groups were lower after taking medicine for there months and stopping taking medicine for nine months（P<0.01,P<0.05）,and the CA125 of the GnRHa and Chinese medicine group fell below the GnRHa group（P<0.01,P<0.05）.3.The levels of serum E₂、FSH、LH of the two groups were lower than the postoperation after taking medicine for there months and stopping taking medicine for nine months（P<0.01,P<0.05）;compared with taking medicine for there months,the levels of serum LH of the GnRHa group was higher after stopping taking medicine for nine months（P<0.01）;compared with the GnRHa group,the levels of serum E₂、FSH、LH of the GnRHa and Chinese medicine group was lower after taking medicine for there months（P<0.05）,and the levels of serum E₂、LH of the GnRHa and Chinese medicine group was lower after stopping taking medicine for nine months（P<0.01,P<0.05）.4.Compared with the postoperation,the levels of VEGF、IL-6 of the two groups were lower after taking medicine for there months and stopping taking medicine for nine months（P<0.01）,and the levels of IL-2 of the GnRHa and Chinese medicine group were higher（P<0.01）,and the levels of IL-2 of the GnRHa group were higher（P<0.05）;compared with taking medicine for there months,the levels of VEGF、IL-6 of the GnRHa group were higher and the levels of IL-2 were lower after stopping taking medicine for nine months（P<0.01）.Compared with the GnRHa group,the levels of VEGF、IL-6 of the GnRHa and Chinese medicine group were lower and the levels of IL-2 were higherafter taking medicine for there months（P<0.01,P<0.05）;the levels of VEGF、IL-6 of the GnRHa and Chinese medicine group were lower and the levels of IL-2 were higher after stopping taking medicine for nine months（P<0.01）.5.The VAS score of the two groups were obviously lower after taking medicine for there months and stopping taking medicine for nine months（P<0.01）,but the GnRHa and Chinese medicine group fell below the GnRHa group（P<0.01,P<0.05）,and the VAS score of the GnRHa group was higher after stopping taking medicine for nine months（P<0.05）,and the difference was statistically significant.6.Compared with the postoperation,the chronic pelvic pain score of the two groups were lower after taking medicine for there months and stopping taking medicine for nine months（P<0.01）,but the chronic pelvic pain score of the GnRHa and Chinese medicine group fell below the GnRHa group,and the difference was statistically significant（P<0.05）.The clinical efficacy of the chronic pelvic pain of the GnRHa and Chinese medicine group was higher than the GnRHa group,and the difference was statistically significant（P<0.01）.7.Compared with the postoperation,the chinese medicine symptoms score of the two group were lower after taking medicine for there months and stopping taking medicine for nine months（P<0.01）;the chinese medicine symptoms score of the GnRHa and Chinese medicine group was obviously lower than the GnRHa group,and the difference was statistically significant（P<0.01,P<0.05）.However the difference of the two groups were not statistically significant in relieving the efficacy of the chinese medicine symptoms（P>0.05）.8.The total effective rate of clinical efficacy of the GnRHa and Chinese medicine group for endometriosis was 96.30%,but the GnRHa group was 66.67%,and the difference was statistically significant（P<0.05）.9.The postoperative recurrence rate of the GnRHa and Chinese medicine group was3.70%,and the GnRHa group was 22.22%,and the difference was statistically significant（P<0.01）.Conclusion:Hu-po san and GnRHa has advantages in decreasing the diameter of the EMs cyst、the levels of serum CA125、symptoms of dysmenorrheathe、chronic pelvic pain、the postoperative recurrence rate、regulating endocrine and immune factors,which will provide a new way to treat the recurrence of endometriosis and a theoretical basis for further research on the recurrence of endometriosis.