| Purpose:This article summarizes and analyzes the medical records of 240 cases of patients with chronic heart failure using traditional Chinese medicine,and discusses their medication laws,hoping to provide some theoretical basis for traditional Chinese medicine treatment of chronic heart failure.Method:In this study,a retrospective analysis method was used to collect 240 cases of patients with chronic heart failure who were treated in the Affiliated Hospital of Liaoning University of traditional Chinese medicine from September 2017 to December 2019 and were definitely diagnosed as chronic heart failure.The medical case database was established by Excel based on SPSS 23.0 statistical software and IBM modeler 18.0 the software carries out frequency analysis,factor analysis,cluster analysis and association rule analysis on gender,age,primary disease,syndrome type of traditional Chinese medicine and treatment formula,so as to explore the law of drug compatibility of traditional Chinese medicine in the treatment of chronic heart failure.Results:1.Frequency analysis: A total of 240 medical cases meeting the criteria were selected.In the general situation analysis,there were more women than men,and the male to female ratio was1: 1.38.The number of patients aged 80-85 was the largest,accounting for 42.5%.Ischemic heart disease is the primary cause of this study.In terms of TCM syndromes,qi deficiency and blood stasis patterns occur most frequently,followed by cardiopulmonary qi deficiency and qi and yin deficiency patterns.This study involved a total of 171 Chinese medicines.The top ten drugs were: Poria,Astragalus,Atractylodes,Angelica,Roasted licorice,Salvia,Cinnamon Twig,Semen Plantaginis,Motherwort,pepperweed seed.Classified by efficacy,the most are tonics,followed by blood circulation and blood stasis medicine,and phlegm and asthma and cough medicine.In terms of four properties,warm drugs,cold drugs and flat drugs appeared most frequently.In terms of five flavors,sweetness medicine,bitterness medicine and spicy medicine appeared most frequently.Regarding the meridian,most of the drugs used in this study belong to the spleen,lung and heart meridians.2.Factor analysis: After factor analysis of high-frequency drugs,12 groups of factors were extracted,which were the first group: Atractylodes,Angelica,Motherwort,pepperweed seed,Lycopus lucidus,Safflower,Peach kernel,Red ginseng.The second group: Pinellia,Tangerine peel,Scutellaria,Magnolia officinalis,Perilla,Bupleurum.The third group:Schisandra chinensis,American ginseng,Polygala.The fourth group: Mulberry peel,Chuanxiong,Codonopsis.The fifth group: Astragalus,Roasted licorice,Salvia.The sixth group: Ophiopogon japonicus,and Rehmannia glutinosa.The seventh group: Radix pseudostellariae,Radix paeoniae rubra.The eighth group:Semen Plantaginis and Aconitum carmichali debx.The ninth group: Semen armeniacae amarae playcodon grandiflorum,Licorice,Fritillaria bulb.The tenth group:Poria,Alisma,Acanthopanacis cortex,Ginseng.The eleventh group: Cinnamon twig,Radix paeoniae alba,pericarpium arecae.The twelfth group:Semen ziziphi spinosae,fossil fragments.3.Cluster analysis: After cluster analysis of high-frequency drugs,five types of drugs were obtained: the first type: Safflower,Peach kernel,Motherwort,pepperweed seed,Semen Plantaginis,Atractylodes,Angelica,Roasted licorice,Lycopus lucidus,Red Ginseng,Poria,Astragalus.The second category: Schisandra chinensis,Polygala,American ginseng,Ophiopogon japonicus,Rehmannia glutinosa,Radix Pseudostellariae,Radix paeoniae rubra,Semen ziziphi spinosae,fossil fragments.The third category: Radix paeoniae alba,Bupleurum,Salvia,Chuanxiong,Codonopsis.The fourth category: Magnolia officinalis,Perilla,Mulberry peel,Pinellia,Tangerine peel,Semen armeniacae amarae,Fritillaria bulb,Scutellaria,licorice,playcodon grandiflorum,pericarpium arecae.The fifth category: Acanthopanacis cortex,ginseng,Aconitum carmichali debx,Alisma orientalis,Cinnamon Twig.4.Analysis of association rules: Through the high-frequency drug association rules,a total of1659 rules were formed.The top three combinations of percent support were Poria and Astragalus,Angelica and Atractylodes,Poria and Atractylodes.After analysis of the association rules between the main syndrome types and high-frequency Chinese medicine,the results suggest that: Qi deficiency and blood stasis types are closely related to mulberry peel and peach kernel;heart and lung Qi deficiency types are closely related to Schisandra chinensis and Chuanxiong;Qi and Yin deficiency types are related to Radix paeoniae rubra and Ophiopogon is closely related.Conclusion:1.Commonly used drugs for treating chronic heart failure in Chinese medicine are Poria,Astragalus,Atractylodes,Angelica,Roasted licorice,Salvia,Cinnamon Twig,Semen Plantaginis,Motherwort,etc.Poria and Astragalus,Angelica and Atractylodes,Poria and Atractylodes have higher correlations,and there are more combinations of Qi-enhancing drugs,cough and asthma drugs,diuretic and soothing drugs,and blood circulation and blood stasis drugs.2.Chronic heart failure is the most common primary disease with ischemic heart disease.TCM syndrome types are mainly Qi deficiency and blood stasis type,cardiopulmonary qi deficiency type,and qi and yin deficiency type.3.Traditional Chinese medicine for the treatment of chronic heart failure involves a total of17 types of drugs,171 flavors of drugs,It involves a wide range of drugs,including Qi tonics such as Astragalus,antitussive and antiasthmatic drugs such as mulberry bark,diuretic and osmotic drugs such as Poria,blood activating and stasis removing drugs such as Salvia miltiorrhiza. |
