Analysis Of TCM Syndrome Types And Related Factors Of Liver Metastasis After Colorectal Cancer Surgery

Purpose:To analyze and explore the Traditional Chinese Medicine(TCM)syndromes and clinical factors affecting liver metastasis in postoperative colorectal cancer patients.Material and method:In this study,retrospective analysis was performed to collect the data of postoperative colorectal cancer patients hospitalized in the department of oncology,affiliated hospital of Liaoning university of TCM from January 2016 to January 2019.Using Microsoft Excel software for colorectal cancer patients’ age,gender,tumor location,depth of invasion(T stage),differentiation level,whether to have lymph node metastasis,chemotherapy,postoperative physics and chemistry result:albumin(ALB),total bilirubin(TBIL),direct bilirubin(DBIL),alanine aminotransferase(ALT),aspertate aminotransferase(AST),carcinoembryonic antigen(CEA)and alpha fetoprotein(AFP),carbohydrate antigen19-9(CA19-9),four diagnostic data of TCM(primary and secondary symptoms,tongue and pulse condition),such as a database of information.SPSS24.0 was used for K-means clustering analysis,X2 test and Logistic regression analysis.Results:1.According to inclusion and exclusion criteria,a total of 101 patients were included in the study,among which 35 had liver metastasis and 66 did not.2.Concluded from K-means clustering analysis,the TCM syndrome types of postoperative patients with colorectal liver metastasis are:syndrome of liver-depression and spleen-deficiency(40%)>syndrome of damp-heat accumulation(28.6%)>syndrome of spleen-kidney yang deficiency(20%)>syndrome of liver-stomach disharmony=syndrome of stasis and toxin internal resistance(7%);while the TCM syndrome types of those without liver metastasis are: syndrome of stasis and toxin internal resistance(33.3%)>syndrome of damp-heat accumulation(31.8%)>syndrome of liver-depression and spleen-deficiency(16.7%)>syndrome of spleen-kidney yang deficiency(15.1%)>syndrome of liver-stomach disharmony(3%).3.There was no statistic difference between the occurrence of liver metastasis in 101 patients with colorectal cancer and gender,age,tumor location,T stage,ALB,TBIL,DBIL and AFP(P>0.05),which prompted not relevant.It is related to differentiation level,lymph node metastasis,chemotherapy,postoperative ALT,AST,CEA,CA19-9 and syndrome of TCM(P<0.05),which prompted relevant.Conclusion:1.The TCM syndrome types of postoperative patients with colorectal liver metastasis are:syndrome of liver-stomach disharmony,syndrome of liver-depression and spleen-deficiency,syndrome of spleen-kidney yang deficiency,syndrome of damp-heat accumulation and syndrome of stasis and toxin internal resistance.2.Patients with liver metastasis are mostly belong to syndrome of liver-depression and spleen-deficiency,and those without liver metastasis are mostly belong to syndrome of stasis and toxin internal resistance.Patients with liver metastasis are mostly belong to syndrome of intermingled deficiency and excess,and those without liver metastasis are mostly belong to excess syndrome.3.The postoperative patients with colorectal cancer,whose primary tumor has a low degree of differentiation with lymph node metastasis,no chemotherapy and postoperative ALT,AST,CEA and CA19-9 increasing,are more likely to have liver metastasis.Such patients should be early screening and followed-up and get early diagnosis and treatment.