Clinical Observation Of Jiajian Shentong Zhuyu Decoction Combined With Irecoxib Tablets In The Treatment Of Residual Pain (blood Stasis) After PVP Operation For Vertebral Compression Fractures

Objective: Based on the theory of three-stage treatment in orthopedics and traumatology department of traditional Chinese medicine,the clinical efficacy and safety of modified Shentong-Zhuyu Decoction in the treatment of residual pain after vertebroplasty for osteoporotic vertebral compression fracture were observed.It provides a new reference for the treatment of postoperative residual pain with traditional Chinese medicine.Methods: According to the diagnostic criteria and TCM syndrome criteria,72 inpatients who met the inclusion criteria in spine surgery of the Hospital from December 2018 to January 2020 were randomly divided into three groups,24 cases in each group(1 case in the western medicine group fell off);the western medicine group was given oral administration of irexib,the Chinese medicine group was given oral administration of jianjianshentongzhuyu decoction,and the combination group was based on irexib Combined with the decoction of reducing body pain and removing blood stasis,it was treated for 2 weeks.The changes of VAS score,ODI score,quantitative score of blood stasis syndrome and hemorheology index before and after treatment were observed and the safety was evaluated.Spss22.0 was used for statistical analysis.Results: There was no significant difference in age,sex,fracture vertebral body,operation time,vertebral compression rate,Cobb angle,anterior height of vertebral body,VAS,ODI,blood stasis syndrome score and hemorheology index among the three groups before treatment(P > 0.05),which was comparable;there was significant difference in VAS,ODI and blood stasis syndrome score between the three groups after treatment and before treatment(P < 0.05),which indicated that all the three groups had drugs It can effectively improve the pain and function and the score of blood stasis syndrome;there was no significant difference in VAS,ODI and blood stasis syndrome scores between the Chinese medicine group and the western medicine group after treatment(P > 0.05),which indicated that the curative effect of the Chinese medicine group and the western medicine group was similar,and the differences were statistically significant compared with the combined medicine group(P < 0.05),which indicated that the combined medicine group was better than the Chinese medicine group and the western medicine group in improving the score of pain,function and blood stasis syndrome The pain relief time(VAS ? 3,vas ? 2)of the three groups were compared respectively.The pain relief time of the combined group(7.79 ± 2.83 days;17.83 ± 4.20)was faster than that of the traditional Chinese medicine group and the western medicine group.There was no significant difference in hemorheology indexes(high shear rate,low shear rate and plasma viscosity)between Chinese medicine group and Western medicine group(P > 0.05),but there was significant difference between Chinese medicine group and Western medicine group(P < 0.05).Efficacy evaluation: there was no significant difference between Chinese medicine group(effective rate 91.30%)and Western medicine group(effective rate 87.50%).There was significant difference between Chinese medicine group,western medicine group and combined medicine group(effective rate 95.83%)(P = 0.037,P = 0.008 < 0.05).Correlation analysis: there was a positive correlation between blood stasis score and VAS score(r = 0.974,P = 0.000 < 0.05);there was a positive correlation between blood stasis score and ODI score(r = 0.944,P = 0.000 <0.05);there was a positive correlation between VAS score and plasma viscosity(R =0.873,P = 0.000 < 0.05),and there was a positive correlation between high shear rate and low shear rate of whole blood viscosity(r = 0.794,R = 950,P = 0.000 < 0.05);there was a positive correlation between the score of blood stasis syndrome and the whole blood viscosity(r = 0.778,r = 0.950,P = 0.000 < 0.05);there was a positive correlation between the score of blood stasis syndrome and the plasma viscosity(r =0.871,P = 0.000 < 0.05).Conclusion: It has a good clinical effect and safety to improve the residual pain and function of PVP patients,and it has a certain popularization value.