The Effect Of Buxin Anshen Decoction On The Treatment Of Tumor-related Insomnia Due To Yin Deficiency And Hyperactivity

Objective:To observe the clinical efficacy of Buxinanshentang in the treatment of cancel-related insomnia of yin deficiency and fire exuberance type.Methods:A total of 60 patients with cancer-related insomnia of yin deficiency and exuberant type in Hunan Cancer Hospital and Affiliated Hospital of Hunan Institute of traditional Chinese Medicine were randomly divided into two groups: experimental group(n=30)and control group(n=30).The course of treatment was one month.The changes of insomnia score(PSQI),yin deficiency and fire exuberance syndrome score and quality of life score of the two groups before and after treatment were compared and statistically analyzed.Results:1.Comparison of insomnia score: the effective rate of insomnia(PSQI)improvement in the test group was 80%(24 /30),and that in the control group was 20%(6/30).The total score of insomnia in the experimental group was significantly lower thanthat before treatment(P<0.01),sleep time and sleep disorder decreased(P<0.05),especially in improving sleep quality,falling asleep time,sleep efficiency and daytime disorder(P<0.01),but there was no significant difference in the use of hypnotic drugs(P>0.05).In the control group,the individual scores of falling asleep time and sleep time were lower than those before(P<0.05),but there was no significant difference in total score and other single scores(P>0.05).The total score of insomnia in the test group was significantly lower than that in the control group(P<0.01),and the time to fall asleep and sleep efficiency in the test group were lower than those in the control group(P<0.05).The improvement of sleep quality,sleep time,sleep disorder and daytime disorder in the test group was significantly better than that in the control group(P<0.01),but there was no significant difference in improving the use of hypnotic drugs between the two groups(P>0.05).2.Comparison of TCM syndrome scores of yin deficiency and excessive fire: the effective rate of improvement of TCM syndrome scores in the test group was 83.3%(25/30),while that in the control group was 20%(6/30).The total score of TCM syndrome in the test group was lower than that before(P<0.05),especially in improving insomnia,palpitation and dreaminess,dizziness and tinnitus,sore waist and knees,five-heart fever,night sweats,forgetfulness and dry mouth and tongu(P<0.01).In the control group,the score of hot flashes and night sweats was higher than before,and the total score and other symptom scores decreased,but there was no significant difference compared with that before treatment(P>0.05).The total score of TCM syndrome in the test group was significantly lower than that in the control group(P< 0.05),and the scores of hot flashes,night sweating and dizziness and tinnitus in the test group were significantly lower than those in the control group(P<0.05).Insomnia and palpitation were significantly lower than those in the control group(P<0.05).3.Comparison of quality of life score: the effective rate of quality of life score improvement was 63.33% in the test group(19/30)and16.67% in the control group(5/30).The quality of life score in the test group was higher than that before treatment(P<0.05),while that in the control group was higher than that before treatment,but there was no significant difference(P>0.05).Compared with the control group,the score of quality of life in the test group was significantly higher than that in the control group(P<0.05).4.Comparison of adverse reactions: there was no obvious abnormality in blood routine,liver function,renal function and ECG in the test group,but there was a slight increase in liver function,the incidence of adverse reactions was 3.33%(1/30)and no obvious abnormality in other safety indexes in the control group.there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:1.Buxinanshentang can effectively improve the state of insomnia,and has obvious advantages in improving sleep quality,shortening falling asleep time,increasing sleep time,improving sleep efficiency,reducing sleep disorders and daytime dysfunction,2.Buxinanshentang can improve the concomitant symptoms of insomnia,especially in improving insomnia,relieving palpitation and dreaming,reducing dizziness and tinnitus,hot flashes and night sweats.3.Buxinanshentang can effectively improve the quality of life of patients,and the side effects are mild,so it is worthy of further clinical research and application.