| Objective:The purpose of this study is to observe the clinical efficacy of nourishing Yin and sleeping prescription in the treatment of Yin deficiency fire,to provide more clinical evidence for insomnia,and to promote the application in clinical practice.Methods:1.Collect into standard of 60 patients with insomnia(Yin deficiency syndrome)fire,derived from October 2015 to October2017 in Hubei province hospital of phoenix mountain and garden outpatient service,the patients into two groups at random,respectively,the treatment group(ziyin fast asleep +estazolam tablets)30 cases and other group 30 cases(estazolam tablets).2.Psychological counseling was given during the treatment,and azolam tablets were given in the control group,and 1mg were given according to the sleep condition,which was taken at night before bedtime.On the basis of the control group,the treatment group was added with the nourishing and nourishing prescription,1 dose per day,respectively in the morning and evening,respectively,about 150 ml each time.The two groups were treated once a week for 28 consecutive days.3.After the treatment,the Pittsburgh sleep quality index(PSQI)score and TCM syndrome integration were observed before and after treatment,and SPSS21.0 software was used for analysis to evaluate its effectiveness.4.In both before and after treatment in both groups need blood,improve the blood routine,liver and kidney function,electrocardiogram examination project,as a safety index,and timely record side effects,fill out the scale.Results:1.General information: before the test will be two groups of gender,average age and average duration,such as comparison,there was no significant statistical difference(P>0.05),comparable.2.The clinical curative effect comparison: 28 days after treatment,the clinical curative effect comparison: the treatment group 30 cases,including 8 cases recovered(26.67%),9 cases were markedly improved(30.00%),effective in 11 cases(36.67%),invalid in 2 cases(6.67%),total effective rate was93.33%;In the control group,there were 30 cases,including2 cases(6.67%),8 cases(26.67%),13 cases(43.33%),7 cases(23.33%),and the total effective rate was 76.67%.The comparison between the two groups was statistically significant(P<0.05).3.Comparison of TCM syndromes: after 28 days of treatment,11 cases(36.67%)were cured,11 cases(36.67%),6 cases(20%)were effective,and 2 cases(6.67%)were ineffective,and thetotal effective rate was 93.33%.The control group recovered1 case(3.33%),10 cases(33.33%),11 cases(36.67%),8 cases(26.67%),and the total effective rate was 73.33%,with statistically significant difference between the two groups(P<0.05).4.Comparison of total score of TCM syndromes: before treatment,total score of the treatment group was(12.60±3.58),and that of the control group was(12.97±4.63).28 days after treatment,the treatment group total integral(5.10±3.68),the control group is(8.53±4.79)points,after treatment between the two way to compare difference was statistically significant(P<0.05),the treatment group to improve TCM syndrome is better than that in control group.5.Comparison of total PSQI score: before treatment,total PSQI score of the treatment group was(13.74±3.26),and that of the control group was(13.43±3.17).28 days after treatment,the treatment group(5.07±1.68)points of PSQI total integral,the control group is(8.06±2.43)points,after treatment between the two way to compare difference was statistically significant(P<0.05),the treatment group to improve sleep quality is better than that in control group.6.Safety evaluation: during the treatment,no adverse drug reactions occurred in both groups;The blood routine,liver and kidney function,electrocardiogram and other laboratory indexes of the two groups before and after treatment showed no obvious abnormality.Conclusion:1.The treatment group was treated with insomnia(Yin deficiency fire syndrome),which was significantly superior tothe control group in clinical efficacy,PSQI integral,Chinese medicine syndrome,and total score.2.Compared with the control group,the treatment group not only improved the sleep disorder,but also effectively alleviated the symptoms of Yin deficiency and fire.3.During clinical observation,no adverse drug reactions occurred in both groups,which did not impair the blood system and liver and kidney function,and the safety was good.Above all,ziyin fast asleep party is not only an effective prescription for the treatment of insomnia,curative effect is distinct,but also improve Yin deficiency caused by the fire five heart be agitated,and many other symptoms,and in the process of taking no obvious adverse reaction occurred,is worth popularizing in clinical use. |
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