Research On Cognitive Function And TCM Syndrome Elements Of Patients With Primary Osteoporosis

Studyl To investigate the level of primary osteoporosis and cognitive function in Beijing communityObjectiveTo investigate the relationship between primary osteoporosis and cognitive function and the distribution of TCM syndromes.Method(1)Recruited 734 middle-aged and elderly people who met the requirements from several communities in Beijing,filled in the questionnaire to collect the basic information,fasted blood check complete bone metabolism related indicators,used mini-mental state examination scale(MMSE)and clock drawing test(CDT)subjects for cognitive function assessment,and used HOLOG dual-energy X-ray absorptiometry measurement instrument on the subj ects,bone density of lumbar spine,left hip and right hip.SPSS24.0 was used for statistical analysis of the collected data,including descriptive analysis,rank sum test,Spearman correlation analysis,linear regression,logistic regression,etc.Result1.Among the 734 subjects,251 were patients with primary osteoporosis,with a total prevalence of 21.8%,of which 15.2%were males and 41.9%were females.2.Normal,insufficient and deficient vitamin D accounted for 1.8%.19.7%and 84.4%respectively in the population over 50 years old in Beijing.3.After adjusting for a variety of factors,the left hip density was positively correlated with MMSE(?=1.913,P=0.002),and there were no statistical differences in lumbar spine density,right hip density,MMSE and CDT(P>0.05).4.25-OHD3 was positively correlated with MMSE(r=0.090,P=0.015),with statistical difference(?=0.042,P=0.008)after adjustment for various factors,but no correlation with CDT(P>0.05).5.In descending order of occurrence frequency,the syndrome elements of primary osteoporosis are:pulp loss(76.1%),kidney deficiency(62.5%),internal heat(39.8%),Yin deficiency(38.2%),Yang deficiency(34.3%),qi deficiency(31.9%),phlegm turbidity(30.3%),blood deficiency(26.3%),blood stasis(18.7%),Yang hyperactivity(15.5%),and spleen deficiency(12.4%).6.Syndromes elements in bone mass normal group,the bone loss,osteoporosis group 3 groups was statistically difference between kidney qi deficiency(P=0.046),(P=0.003),blood deficiency(P=0.013),Yin deficiency(P=0.001),Yang deficiency(P?0.013),decrease pulp(P=0.003),Yin deficiency,after adjustment for confounding factors is still statistically difference between pulp decreased in 3 groups(P=0.013,P=0.041).7.The scores of syndrome elements of kidney deficiency,Yang deficiency,pith loss,phlegm turbidity and blood stasis were statistically significant with MMSE(=-0.044,P=0.040).Beta=0.046,P=0.046;Beta=0.087,P=0.000;Beta=0.051,P=0.036;=-0.051,P=0.037),multivariate linear stepwise regression analysis showed that the pith score was statistically significant with MMSE(=-0.087,P=0.000).Conclusion1.There is a certain correlation between primary osteoporosis and cognitive function decline,showing a trend of decreased cognitive function with less bone mass.2.Medullary degeneration is the most important syndrome factor in primary osteoporosis and is associated with cognitive decline.3.Kidney deficiency,qi deficiency,blood deficiency,Yin deficiency,Yang deficiency and pith deficiency are risk factors affecting bone mass,among which pith deficiency and Yin deficiency are independent risk factors for primary osteoporosis.Kidney deficiency,Yang deficiency,pith deficienc,phlegm turbidity and blood stasis are related to MMSE.The higher the syndrome factor score is,the more the cognitive function will decline.Medullary degeneration is the most essential syndrome of cognitive impairment.4.Decreased vitamin D levels may be a potential factor for cognitive decline in primary osteoporosis.Study2 To study the relationship between postmenopausal osteoporosis and mild cognitive imp airmentObjectiveTo investigate the bone mass and distribution of TCM syndromes in postmenopausal patients with mild cognitive impairment(MCI)MethodForty postmenopausal women were recruited from the outpatient department of dongzhimen hospital and the community.Basic information of all subjects was collected,complete a complete set of neuropsychological evaluation and serum bone metabolism indexes examination,and lumbar spine,left hip and right hip bone density examination were performed with HOLOG dual-energy X-ray bone density meter.SPSS24.0 was used for statistical analysis of the collected data,including descriptive analysis,rank sum test,binary logistic regression and other methods.Result1.In the MCI group,there were 10 patients with osteoporosis,accounting for 62.5%of the group;in the cognitive normal group,there were 6 patients with osteoporosis,accounting for 25%of the group.2.There was a correlation between postmenopausal osteoporosis and mild cognitive impairment(P=0.021),and statistical significance remained after adjusting for confounders(P=0.023,P=0.017).3.The common syndromes of postmenopausal MCI patients are pith loss,kidney deficiency,qi deficiency,phlegm turbidity,Yin deficiency and internal heat,accounting for 87.5%,81.3%,68.8%,68.8%,56.3%and 56.3%,respectively.4.There was a positive correlation between osteocalcin level and MCI(=0.234,P=0.016),and the correlation remained after confounding factors(P=0.021,P=0.003).Conclusion1.The prevalence of osteoporosis in MCI patients is significantly higher than that in those with normal cognitive function,and postmenopausal bone loss may lead to cognitive decline.2.Osteocalcin changes may be a common pathological factors of postmenopausal osteoporosis and mild cognitive impairment.3.Medullary reduction and kidney deficiency are the main TCM syndrome elements of mild cognitive impairment,but it is still necessary to expand the sample size for further study.