Analysis Of The Curative Effect Of Xiaobian Decoction Combined With Compound Glycyrrhizin In The Treatment Of Psoriasis Vulgaris And Its Effect On Serum IL-17 And IL-22

The first part:Clinical observation of Combination therapy for Xiaobi Decoction unite Compound Glycyrrhizin.Objective:To survey the security and validity of Combination therapy for Xiaobi Decoction unite Compound Glycyrrhizin.Methods:60 patients who with psorasis vulgaris will be randomly divided into 2 groups.30 cases in control group will be treated with Xiaobi Decoction.30 cases in treatment group will be treated with Xiaobi Decoction unite Compound Glycyrrhizin.And value the therapeutic effect by comparing PASI scores 4 weeks later,and study the results with SPSS20.0.Results:The total effective rate of treatment group is 86.67%,effective rate of control group is 66.67%.In the clinical efficacy,PASI scores in patients with psorasis vulgaris,Xiaobi Decoction unite Compound Glycyrrhizin was significant better than that in the control group(P<0.05).Conclusion:Xiaobi Decoction unite Compound Glycyrrhizin is more effective and safe than Xiaobi Decoction in treating patients with psorasis vulgaris-Part two:Xiaobi decoction unite Compound Glycyrrhizin effects of changes in level of serum IL-17,IL-22.Objective:Primarily,to look into the connection between psorasis vulgaris and the changes of two serum indexes.Secondary,to value the effect of Xiaobi Decoction unite Compound Glycyrrhizin objectively and exactly by studying on the changes of serum levels,in the meantime,by observing the influence of Xiaobi Decoction unite Compound Glycyrrhizin to the serum levels of IL-17,IL-22,further to research the mechanism of Xiaobi Decoction unite Compound Glycyrrhizin treat patients with psoriasis vulgaris,as a result of offer demonstration to clinical theatment for psorasis.Methods:Randomly selected treatment group and control group patients for 20 patients each group.To gather before treatment and after treatment venous blood 5ml,in the meantime,selected 20 healthy volunteers as blank controls,Separat serums to measure serum of IL-17,IL-22 levels with SPSS20.0 statistical analysis.Results:Measuring serum of IL-17,IL-22 value by the statistical analysis,analysis consequence:serum exponent in patients with psoriasis were higher than normal,(P<0.05).Serum IL-17,IL-22 of the treatment group were lower than the control group(P<0.05).The serum levels of IL-17,IL-22 in patients were positive correlation to the PASI scores(0<r<1,P<0.05).Conclusion:We can find that IL-17,IL-22 are closely related with psorasis.The Xiaobi Decoction unite Compound Glycyrrhizin in reducingIL-17,IL-22 level better than sole Xiaobi Decoction.The changes of serum IL-17,IL-22 can reflect the change of psorasis vulgaris.