Clinical Observation Of Simiao Yongan Ultrafine Granules In The Treatment Of Chemotherapy-induced Phlebitis

Objective: To observe the clinical efficacy and safety of Si Miao Yong An ultra micro particle external application in the treatment of chemical phlebitis.Methods: Seventy cases were randomly divided into experimental group(n = 35)and control group(n = 35).The treatment group was treated with Simiayong'an ultrafine granule wet compress and the control group with 50% magnesium sulfate wet compress.For examination and other reasons,5 cases were eliminated in the treatment group and 5 cases in the control group.The effective cases were 30 cases in the treatment group and 30 cases in the control group.The control group was given50% magnesium sulfate gauze wet compress,observed and recorded the patients' phlebitis condition 5 days later to evaluate the curative effect,and observed the local curative effect of the patients.The scores of medical syndrome,quality of life(Karschner score,general physical examination items,pain relief,adverse drug reactions,etc.)were statistically analyzed.Results:(1)After 5 days,the efficacy of the two groups was compared.The total effective rate in the treatment group(90.00%)was higher than that in the control group(66.67%).The efficacy was evaluated by X2,X2=4.812 P=0.028<0.05,which was statistically significant.The use of Miaoyong An ultramicro-particles to treat chemical phlebitis can significantly improve the local therapeutic effect.(2)After treatment,the treatment group and the control group had chemical phlebitis grading,Z=-2.85,P=0.004<0.05,with statistical significance,indicating that the treatment group could significantly improve the grading of chemical phlebitis.(3)Before and after the two groups,the scores of TCM syndromes after treatment in both groups decreased before treatment,which was statistically significant(P<0.05),indicating that both groups had improved symptoms after treatment.Comparing the two groups of patients,there was no significant difference in TCM syndrome scores before treatment(P>0.05).After treatment,TCM syndrome scores in the treatment group improved significantly compared with the control group(t =-2.41 P = 0.02 <0.05,there are statistics Learn the difference).(4)Comparing the efficacy of TCM syndromes between the two groups of patients,the total effective rate was 86.67% in the treatment group and 60.00% in the control group,and the treatment group was superior to the control group,with X2 = 5.46 P = 0.02 <0.05,which was statistically significant.(5)Within the group comparison,the KPS scores after treatment in the two groups were significantly higher than before treatment(P<0.05),indicating that both the treatment group and the control group can increase the KPS score of the patients;The KPS scores in the first two groups were not statistically different;after treatment,the KPS scores in the treatment group were significantly higher than those in the control group(t=2.78 P=0.007<0.05),and there was a statistical difference,indicating that Si Miao Yong An Tang ultramicro particles external treatment It has advantages in improving the quality of life of patients.(6)Comparison of symptom relief in the two groups,the data of the two samples were graded data.Using a two-sample rank sum test,Z=-3.87 P=0.00<0.05,the results showed that the treatment group could be in a shorter time.Internal control symptoms were superior to the control group,and the time of symptom remission between the two groups was statistically significant.(7)Comparing the pain relief after treatment between the two groups,the pain relief in the observation group was significantly better than that in the control group(X2=5.96,P=0.015>0.05).The difference was statistically significant.(8)Comparison of safety: There is no statistical significance between the two indicators of safety.Conclusion: In this clinical observation,the treatment group was superior to the local treatment curative effect of chemical phlebitis,the improvement of chemical phlebitis grading,the overall curative effect of TCM syndromes,the improvement of TCM symptom scores,the improvement of KPS scores,the time of symptom relief,and pain relief.Control group.