Synthetic Research And Process Design Of Chlorfenapyr

Amicarbazone is a triazolinone herbicide which was developed by Bayer Company and it is a photosynthesis inhibitor,by inhibiting photosynthesis of susceptible plants,electron transfer and interference control annual bluegrass,and can effectively control sugarcane annual grass and broad leaf weeds on cor.By referring to related literatures and patents,the best way for industrial production is selected,which bears the advantages of simple operation,mild conditions and high yield.At the same time,we optimized the corresponding reaction conditions of two important intermediate of amicarbazone to get the best yield and designed the various stages of the flow chart,provide a basis for industrial production.(1)In the process of synthesis of tert-butyl isocyanate taking t-butylamine,phosgene,hydrogen chloride as the material in the first step of this experiment,by discussing its temperature synthesis,optimum reaction conditions are a temperature of t-butylamine hydrochloride salt is 1-10 ?,temperature of the reaction with phosgene is 140 ?.(2)In the process of synthesis of triazolinones taking isobutyric acid,hydrazine hydrate,phosgene,triphosgene as the material in the second step of this experiment,in order to obtain the optimum reaction conditions,we design orthogonal experiment,change the reaction temperature,time,solvent,feed ratio and other conditions.(3)In the process of synthesis of amicarbazone by taking t-butylamine and triazolinones as the material in the third step of this experiment,at the same time,we find the best reaction conditions by optimizing the synthesis conditions.(4)Finally,we designed the production process of amicarbazone based on practical production requirements,provided a basis for industrial production.