Sensitivity Enhanced Surface Plasmon Resonance Biosensor By Two-dimensional Materials

Surface Plasmon Resonance?SPR?method has become a hotspot in the field of optical sensing because of its fast response speed,high sensitivity,low sample requirement,label-free and real-time detection and Increasing the SPR detection sensitivity is a constant concern in this research field.The use of various materials to modify SPR for increasing sensitivity has been continuously reported,and experimental work based on two-dimensional material sensitization SPR sensing is rarely seen.In this paper,the excitation principle of surface plasmon resonance is introduced first,and the research status of the enhancement of the sensitivity of SPR sensor at home and abroad is analyzed.The use of two-dimensional material to enhance the performance of SPR sensor is proposed as the research object of this paper.The paper makes the fabrication of SPR sensor,tests the optical properties of three two-dimensional materials?molybdenum diselenide,molybdenum disulfide,and graphene?,modifies the modification of two-dimensional materials to the SPR sensor,and completes the modified SPR sensor properties.Experimental results analysis and discussion are presented.The main research work is as follows:?1?SPR sensors based on molybdenum disulfide?MoS₂-SPR?nanosheet modification.This paper introduces the photoelectric properties of molybdenum disulfide nanomaterials,describes the fabrication process of MoS₂-SPR sensors,and completes the material structure observation of MoS₂-SPR sensors.Finally,the sensor performance of the sensor is tested and analyzed and the results discussed.Studies have shown that the SPR sensor with two depositions of MoS₂ nanosheets has the highest sensitivity and can reach 2793.5 nm/RIU.Compared with the unmodified SPR sensor,the sensitivity of the Mo S₂-SPR sensor is increased by 30.67%.?2?Studies were based on the MoS2 nano-sheet modified SPR sensor.The photoelectric properties properties of molybdenum diselenide nanomaterials were introduced.The observation of the structure of the MoSe₂-SPR sensor was completed.Finally,the sensor's sensing performance was tested and the results were analyzed and discussed.Studies have shown that the SPR sensor with two depositions of MoSe₂ nanosheets has the highest sensitivity of 2524.8 nm/RIU.Compared with the unmodified SPR sensor,the sensitivity of the MoSe₂-SPR sensor is increased by 36.34%.?3?SPR sensor based on graphene nanosheets modified.The optoelectronic properties of graphene nanomaterials were introduced,and the sensor structure observations were completed.Finally,the sensing characteristics of the sensor were tested with ethylene glycol configured refractive index solution and fetal bovine albumin solution,and the results were analyzed.The study shows that the spin-coated three-graphene dispersion SPR sensor has the highest sensitivity,up to 2715.1nm/RIU,and it is increased by 20.25%compared with the unmodified SPR sensor.The refractive index sensing test was carried out with the fetal bovine albumin biological solution.When the graphene was spin-coated twice,the sensitivity reached highest-4029.0 nm/RIU.Compared with the refractive index liquid,the optimum sensitivity of the three-graphene SPR sensor was higher,and its sensitivity was 48.39%.The innovation of this article:?1?MoS₂,molybdenum disulfide,and graphite are used to modify SPR sensors.?2?The refractive index sensing performance of the two-dimensional material modified SPR sensor was experimentally studied,and the biological experiments were performed on the graphene modified SPR sensor.