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Habitual Short Sleepers Default Network And Working Memory Abnormalities,a FMRI Study

Posted on:2019-05-28Degree:MasterType:Thesis
Country:ChinaCandidate:Z Y LuoFull Text:PDF
GTID:2405330596959153Subject:Applied Psychology
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Short sleepers are healthy people whose actual sleep time is ? 6 hours per day.For a single individual,maintaining a proper length of sleep every day is a basic guarantee for maintaining the physical and mental health and working life of the individual.Most people report a series of physical and psychological discomforts when the daily sleep time is less than 6 hours.The study of short-sleepers can reveal that they remain physiological and psychological during extreme sleep.Healthy behavioral characteristics and underlying neural mechanisms.However,researchers are currently paying less attention to the group of short-sleepers and have not explained the anti-sleep pressure traits of short-sleepers.The sleep time of individuals is determined by the regulation mechanism of sleep homeostasis.The mechanism of sleep homeostasis mainly includes circadian rhythm and homeostasis sleep drive.Therefore,it is mainly from the circadian rhythm and sleep characteristics of short-sleepers to study the behavior characteristics of short-sleepers..Review some behavioral studies of short-sleepers,we found that the total sleep length and sleep latency of short-sleepers were significantly shorter than those of healthy non-short sleepers,and that short-sleepers had significantly longer wake-up times than non-short sleepers.The sleep habits and characteristics of this group are different from those of non-short sleepers,and the physiological indexes of short-sleepers are also different from those of non-short sleepers,including the level of cortisol changes and the level of body temperature changes.the level of change in melatonin and other physiological indicators.Recalling the study of sleep pressure and default network,it is found that with the increase of sleep pressure,the default network in the resting state brain network and its anti-correlation network nodes have a decrease in the connection strength,but this kind of research does not involve the default network internals.In order to select habitual short sleepers who denies that has functional impairment,and to study the changes in sleep habits that such short sleepers have under high sleep pressure,we propose a study 1: in college students In the group,the group chose to deny the group of short-sleepers who had functional impairment,and to examine the differences in sleep habits and characteristics of this group and healthy non-short sleepers.In order to investigate whether the habitual short-sleepers who deny cognitive impairment are facing changes within the default network in the face of more sleep pressure,we propose a study 2: using the independent component analysis method to examine short-sleepers The resting state defaults to the change of blood oxygen signal level inside the network,and observes the difference between the short-sleeper who subjectively denies that he has functional impairment and the default network of healthy non-short sleepers.In order to verify that the short-sleepers who subjectively deny their cognitive impairment are subjectively deny that they have cognitive impairment,or subjectively deny that they have cognitive impairment,the working memory task of habitual short-sleepers is affected by sleep.With the influence of stress,we propose a study 3: using the n-back memory task to examine the characteristics of brain activation when a short-sleeper performs a working memory task.In Study 1,through the Pittsburgh Sleep Scale Questionnaire,it was found that the habitual short-sleep group had daytime dysfunction and the sleep latency was significantly longer than that of the control group,but the sleepiness of the short-sleep group was higher than that of the control group,and it was generally believed that there was a certain existence.The degree of insomnia,but they subjectively deny that their daytime function declines.In Study 2,independent component analysis was used to explore the default network of short-sleepers with subjective denial of cognitive impairment.In the study of functional connection of predecessors,it was pointed out that high steady-state sleep stress would cause default network and other brain networks.The connectivity is reduced.In this study,it was found that the short-sleep group had abnormal activation of the brain in the region,and at the same time,there was a negative correlation between the caudate nucleus and the actual sleep duration of the short-sleep group,and the cerebellar 4 and 5 regions were negatively correlated with the sleep efficiency.Short-sleepers may be caused by cognition and emotional stress induced by steady-state sleep stress,resulting in abnormal activation of cingulate gyrus and caudate nucleus,while short-sleepers may subjectively deny that functional impairment may be caused by short-sleeping groups.Inaccurate.Therefore,a short sleeper who subjectively denies that he has a decline in function may overestimate his daytime function.In study 3,it was found that with the increase of the difficulty of working memory,the dorsolateral prefrontal lobe and the caudate nucleus appeared,and the activation of the right lingual gyrus was enhanced.In the 3-back working memory task,the negative activation area continues to decrease,indicating that as the difficulty of the task continues to increase,the short-sleep group maintains difficulty in awakening,and is affected by noise and task load,and emotional abnormalities occur.Therefore,short sleepers may overestimate their daily functional status.In the activation of the N-back mission state associated with the actual sleep duration,as the difficulty of the task increases,the activation of the hippocampus on the right side of the short-sleeper decreases.As the difficulty of the task increases further,in the brain activation map of the 3-back working memory task associated with the sleep duration,the group of short-sleepers still exhibit activation changes of the right hippocampus,and the right front anterior cingulate Regional changes.Explain that in working memory,the brain area associated with sleep duration includes the visual cortex,the hippocampus,and the cingulate area.Overall,the study found that(1)subjectively denied short-sleepers with functional loss had significantly higher daytime dysfunction than the control group,and the sleep latency was significantly longer than the control group,but they denied that they had reduced daytime function;(2)subjective It is denied that the short-sleeping person with functional loss has an abnormal activation.At the same time,there is a negative correlation between the caudate nucleus and the actual sleep duration of the short-sleep group,and the cerebellum 4 and 5 areas are negatively correlated with the sleep efficiency.Short-sleepers may be due to cognitive and emotional stress induced by steady-state sleep stress,which leads to inaccurate self-awareness of cingulate gyrus and activation of the caudate nucleus.(3)In working memory,the brain area associated with sleep duration includes the visual cortex,the hippocampus,and the buckle back zone.The short-sleep group maintained difficulty in awakening and was affected by noise and task load,and emotional abnormalities occurred.Therefore,short sleepers may overestimate their daily functional status.
Keywords/Search Tags:Short Sleepers, sleep Pressure, The Default Network, Working Memory
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