| Adolescents’ externalizing problem behavior has received extensive attention.How genetics and environment jointly affect adolescents’ externalization behaviors is one of the hot issues in current development research.In this study,GABRA2 gene polymorphism represents genetic factors,parental monitoring,and deviant peers represent environmental factors.Based on the Differential Susceptibility Model and Cumulative Risk Model,the genetic and environmental factors were used to investigate the influences of adolescents’ externalizing problem behavior.In this study,666 students from junior student of grade 1 were selected as subjects.DNA extraction and genotyping by collecting test saliva.Questionnaire survey was used to measure the scores of the parental monitoring,deviant peers,and externalizing problem behavior.On this basis,we investigated the effect of GABRA2 gene polymorphisms and deviant peers interactions on the adolescents’ externalizing problem behavior and the cumulative effect of risk genotypes.The main findings of the present study were as follows:(1)Deviant peers play a mediating role between parental monitoring and adolescent externalizing problem behavior.(2)Genotype at rs279826、rs279827、rs279858 polymorphism in the GABRA2 gene significantly interacted with deviant peers in predicting adolescents’ externalizing problem behavior.In the environment of high deviant peers,teenagers carrying the GG gene are more likely to develop externalization problems than teenagers carrying the A genotype.In the environment of low deviant peers,the teenagers carrying the GG gene appear to be less externalizing problem behavior than the teenagers carrying the A gene.(3)The interaction effects of GABRA2 accumulation risk genes and deviant peers were significant for the behavior prediction of adolescent externalization,and the cumulative risk effect of multiple sites was better than that of single site. |
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