| Objective To observe the clinical efficacy of Angelica porridge for enriching blood with qi and blood deficiency in patients with cancer-related fatigue(CRF),in order to find a suitable diet therapy to reduce the CRF of these patients,improve their quality of life,and provide a basis for the clinical application of diet therapy.Methods This study adopted a randomized controlled study design.From May 2018 to December 2019,80 hospitalized patients with CRF due to qi and blood deficiency syndrome in a Third-class hospital were selected,and were completely randomly divided into two groups: the control group(40 cases)and the experimental group(40 cases).The control group was given routine treatment and nursing measures,the experimental group took Angelica porridge for enriching blood on the basis of the control group,twice a day,200 ml each time,in the morning and evening with two meals for 2 weeks.The Cancer Fatigue Scale(CFS),the Quality Of Life(QOL),and the Karnofsky Performance Status Scale(KPS)were used respectively before and 2 weeks after the intervention to observed the changes of CRF,quality of life and functional status of patients in the two groups before and after intervention,and took blood samples to check blood routine and blood biochemistry,and counted the changes in the quantity of white blood cells,red blood cells,platelets,hemoglobin,total protein and albumin.Meanwhile,the occurrence of adverse reactions was observed during the whole experiment period,and the data were statistically analyzed.Results 1 Study Completion In this study,a total of 80 hospitalized patients with CRF due to deficiency of qi and blood were included.No patients fell off during the whole intervention period,and all the patients completed the test.2 Baseline information Before the intervention,there was no significant difference in age,gender,education level,payment method of medical expenses,tumor grade,tumor metastasis,tumor type,and tumor treatment methods between the two groups of patients(P>0.05).And there was also no significant difference in CRF,quality of life,functional status,white blood cells,red blood cells,platelets,hemoglobin,total protein,albumin counts and abnormal rates between the two groups of patients(P>0.05).It shows that the baseline data is comparable.3 Comparison of evaluation indexes between two groups of patients after intervention 3.1 Comparison of CFS scores(1)Comparison within the group The control group: compared with before the intervention,the differences in the physical fatigue,emotional fatigue,cognitive fatigue score and CFS total score of the patients after the intervention were statistically significant(P<0.05).The experimental group: compared with before the intervention,there were statistically significant differences in the physical fatigue,emotional fatigue,cognitive fatigue score and CFS total score of the patients after the intervention(P<0.05).(2)Comparison between groups After the intervention,the physical fatigue score,emotional fatigue score,cognitive fatigue score and total CFS score of the experimental group were lower than those of the control group,and the differences were statistically significant(P<0.05).3.2 Comparison of QOL scores(1)Comparison within the group The control group: compared with before intervention,the difference in quality of life score after intervention was statistically significant(P<0.05).The experimental group: compared with before intervention,the difference in quality of life score after intervention was statistically significant significance(P<0.05).(2)Comparison between groups After the intervention,the total QOL score of the test group was higher than that of the control group,and the difference was statistically significant(P<0.05).3.3 Comparison of KPS scores(1)Comparison within the group The control group: compared with before intervention,the difference in functional status score after intervention was not statistically significant(P=0.103).The experimental group: compared with before intervention,the difference in functional status score after intervention was statistically significant significance(P<0.001).(2)Comparison between groups After the intervention,the total KPS score of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).3.4 Comparison of blood routine related indexes and serum protein(1)Comparison within the group The control group: compared with before intervention,the white blood cell,red blood cell,platelet,hemoglobin,total protein,and albumin counts after intervention were not statistically significant(P>0.05).The experimental group: compared with before intervention,the white blood cell,red blood cell,platelet,hemoglobin,total protein,and albumin counts were not statistically significant(P>0.05)after intervention.(2)Comparison between groups After the intervention,the counts of white blood cell,red blood cell,platelet,hemoglobin,total protein,and albumin counts of the experimental group were not statistically significant(P>0.05)compared with those in the control group.However,after intervention,the abnormal rate of white blood cells(40%)and hemoglobin(70%)in the experimental group was lower than that in the control group(55%),and the difference was statistically significant(P< 0.05).3.5 During the entire intervention process,no adverse events related to the intervention measures of this study were found in patients.Conclusion 1Angelica blood-enriching porridge can improve the physical fatigue,emotional fatigue and cognitive fatigue of patients with CRF due to deficiency of both qi and blood.2Angelica blood-enriching porridge can improve the quality of life of patients with CRF due to deficiency of both qi and blood.3Angelica blood-enriching porridge can improve the functional status of patients with CRF due to deficiency of both qi and blood.4Angelica blood-enriching porridge also has a certain regulatory effect on red blood cells,white blood cells and hemoglobin in the blood. |
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