Observation Of The Therapeutic Effect Of Huosu Yangwei Oral Liquid On Atrophic Gastritis By Pathological Changes

Objective: The aim of this study is to observe the therapeutic effect of Huosu Yangwei Oral Liquid on chronic atrophic gastritis through prospective clinical control study.The effect of Huosu Yangwei Oral Liquid on chronic atrophic gastritis was clarified by comparing the degree of atrophy of gastric mucosa,intestinal metaplasia,chronic inflammation,gastroscopic manifestations and clinical symptom scores.In order to explore new methods for treating precancerous diseases and precancerous lesions of gastric cancer with traditional Chinese medicine,and promote the development and clinical application of traditional Chinese medicine.Methods:The clinical observation of 66 patients with chronic atrophic gastritis has completed in this study.All patients were randomly divided into experimental group and control group according to 1:1.The experimental group was given Huosu Yangwei Oral Liquid once,twice a day;the control group was given Weifuchun Tablet three times a day,four tablets each time.The medication cycle is 24 weeks,during the research the relevant drugs which affect the study has been avoided.The gastric mucosal atrophy,intestinal metaplasia,chronic gastric mucosal inflammation,gastric mucosal endoscopic manifestations,clinical symptom scores and safety indicators were compared between the two groups before and after treatment.Through the above observation indicators,the clinical efficacy of Huosu Yangwei Oral Liquid in the treatment of chronic atrophic gastritis was evaluated comprehensively and scientifically.Results:1.The improvement of gastric mucosal pathology: After treatment,the effective rate of gastric gland atrophy in the treatment group was 60.61%,and that in the control group was 39.39%.There was a statistically significant difference in the treatment of gastric gland atrophy between the two groups(P<0.01).There was significant difference in OLGA grading between the two groups(P<0.01).After treatment,the improvement rate of intestinal metaplasia was 63.64% in the treatment group and 33.33% in the control group.There was a statistically significant difference in the improvement of intestinal metaplasia between the two groups after treatment(P<0.01);There was significant difference in OLGIM grading between the two groups after treatment(P<0.01).After treatment,the effective inflammation of gastric mucosa in the treatment group was improved by 45.45%,and the control group was 27.27%,There was astatistically significant difference in the efficacy of chronic inflammation of gastric mucosa between the two groups(P<0.01).2.Curative effect of endoscopic mucosal lesions : After treatment,the effective rate of gastric mucosal lesions in the treatment group was 72.73%,and that in the control group was 51.52%.There was a statistically significant difference in the curative effect of gastroscopic mucosal lesions between the two groups(P<0.01).3.TCM syndrome effect: After treatment,the scores of TCM syndromes in the two groups were significantly lower than those in the group.There was a statistically significant difference in the efficacy of TCM syndrome between the two groups(P<0.05).4.Safety indicators: routine biochemical tests has been performed in our hospital before and after treatment,and no clinically significant change has been found.Conclusion:Huosu Yangwei Oral Liquid can improve gland atrophy,intestinal metaplasia and chronic inflammation of gastric mucosa,and its therapeutic effect is better than control group.The prescription of Huosu Yangwei Oral Liquid is based on the pathogenesis of chronic atrophic gastritis characterized by deficiency,stagnation,dampness and blood stasis.It has obvious clinical application effect and highlights the advantages of traditional Chinese medicine theory in guiding the treatment of chronic diseases of digestive system and precancerous lesions.