Clinical Observation And Study Of Hongyu Lianbai Granule On The Protection Of Organs In Sepsis With Qi Syndrome

Objective:To explore the protective effect of modified Shengjiang Powder on organs of patients with sepsis of Qi syndrome.To study the effect and mechanism of modified Shengjiang Powder on organ protection of sepsis Qi syndrome.The application of traditional Chinese medicine to solve the clinical problem of lack of organ protection in sepsis Qi syndromeMethods:Seventy patients with sepsis in ICU and emergency observation ward of Yueyang Integrated Traditional Chinese and Western Medicine Hospital affiliated to Shanghai University of Traditional Chinese Medicine were randomly divided into two groups:experimental group(n=35)and control group(n=35).The experimental group was treated with modified ascending and descending dispersions,while the control group was treated with conventional Western medicine.The course of treatment was 7 days.The TCM syndrome scale,APACHE ? score,SOFA score,diagnostic grade of gastrointestinal dysfunction,WBC,NE%,PCT,lactic acid,heart function,liver function,lung function,renal function and coagulation function were compared between the two groups before treatment,the first day after treatment,the third day after treatment and the seventh day after treatment.The intra-group and inter-group comparisons were made.The test data were analyzed by SPSS 22.0 softwareResults:1.Before treatment,there were no significant differences in TCM syndrome score,APACHE? score,SOFA score,diagnostic grade of gastrointestinal dysfunction disease,white blood cells,neutrophils,lactic acid,platelets,D-Di,cTnI,CK-MB,ALT,total bilirubin,PaO2/FiO2,creatinine between the experimental group and the control group(P>0.05);2.Before and after treatment,there were no significant differences in TCM syndrome score between the control group and the control group(P>0.05).There were statistical differences in the scores of procalcitonin,PaO2/FiO2,creatinine and total bilirubin on the 3rd and 7th day after treatment(P<0.05);APACHE ? score,SOFA score,white blood cells,platelets,PT,cTnI,CK-MB on the 7th day after treatment(P<0.05);there were statistical differences on the 1st,3rd and 7th day after D-Di treatment(P<0.05);there were statistical differences on the 3rd day after ALT treatment(P<0.05).Difference(P<0.05).3.Compared before and after treatment,APACHE ?,TCM syndrome score,SOFA score,leukocyte,procalcitonin,lactic acid,platelet,cTnI,ALT,total bilirubin,PaO2/FiO2 had statistical difference on the 3rd and 7th day after treatment(P<0.05);D-Di and creatinine had statistical difference on the 1st,3rd and 7th day after treatment(P<0.05);the diagnostic grade score of gastrointestinal dysfunction and neutrality were significant.There were significant differences in granulocytes,PT and CK-MB on the 7th day after treatment(P<0.05)4.Compared with the control group,the scores of TCM syndromes,neutrophils,lactic acid,platelets,D-Di,ALT,creatinine,PT,CK-MB,total bilirubin,PaO2/FiO2 had statistical differences on the 7th day after treatment(P<0.05),APACHE ?,SOFA scores,white blood cells,procalcitonin,cTnI had statistical differences on the 3rd day and 7th day after treatment(P<0.05)Conclusion:1.Modified Shengjiang Powder can improve the organ scoring standards and functional indicators of patients with Qifen syndrome sepsis,and play an important role in organ protection of patients with Qifen syndrome sepsis2.Modified Shengjiang Powder can significantly improve inflammation index and coagulation function index,reduce organ damage,improve blood perfusion of organs,and play the role of organ protection.