Clinical Efficacy Evaluation And Long-term Follow-up In The Treatment Of Chronic Heart Failure With Insomnia By Addition And Subtraction Of Yangxin Anshen Prescription

Objective: Yangxin Anshen prescription is derived from Suanzaoren decoction of Synopsis of Golden Chamber,for treating chronic heart failure with insomnia.This study initially evaluated the clinical efficacy of Yangxin Anshen prescription by observing relevant indicators before and after the treatment and long-term follow-up,so as to provide some objective basis for clinical application and further research.Methods: patients with chronic heart failure combined with insomnia who met the inclusion criteria were randomly divided into the treatment group and the control group.A total of 75 patients were included in the treatment group and the control group.The control group was treated with conventional western medicine,and the treatment group was treated with Yangxin Anshen prescription granules on the basis of the control group.The course of treatment was 1 month.Observed and recorded before and after treatment in patients with TCM syndrome of TCM syndrome integral,curative effect,NYHA heart function classification,Pittsburgh sleep quality score and Minnesota quality of life score,blood pressure,heart rate,and followed up for rate of rehospitalization within six months,incidence of MACE,using SPSS statistical software for statistical analysis of data from 22.0 to assess differences between the two groups.Results: a total of 150 patients were included in the study,including 1 case falling off and 1 case eliminating in the control group.Finally,75 cases in the treatment group and 73 cases in the control group were collected.There was no significant difference in gender,age,NYHA classification of cardiac function,TCM syndrome score,PSQI score,Minnesota quality of life score,blood pressure,and heart rate between the two groups(P>0.05),suggesting comparability.After treatment,the two groups after treatment of TCM syndrome integral,heart function grading,Pittsburgh sleep quality score,quality of life score of Minnesota,blood pressure,heart rate can improve the than before treatment(P<0.05),the treatment group in TCM syndrome integral,curative effect of TCM syndrome curative effect,and cardiac function,Pittsburgh sleep quality score,the improvement of the quality of life scoresof Minnesota was better than control group,in terms of blood pressure,heart rate,and the control group no significant difference(P>0.05),the hospitalization rate and the incidence of MACE again within half a year in two groups had no significant difference(P>0.05).Considering the situation of patients in the control group who were given estazolam plus,to exclude the interference of estazolam on the experimental results,two subgroup analyses were added,namely 75 patients in the treatment group and 30 patients in the control group who were given estazolam,and43 patients in the treatment group and the control group who were not given estazolam.The subgroup analysis results were basically the same as the overall analysis results,and the effect of estazolam could be excluded.The only difference was that there was no significant difference in the heart rate of patients in the control group receiving estazolam compared with those before treatment(P>0.05).Conclusion: Yangxin anshen prescription combined with conventional western medicine has a definite clinical efficacy in the treatment of chronic heart failure with insomnia.It has obvious curative effect on TCM syndrome,cardiac function,sleep quality and quality of life of patients with chronic heart failure with insomnia,but has no obvious curative effect on blood pressure,heart rate,rate of re-hospitalization within half a year and incidence of MACE.Through meta-analysis of the treatment of chronic heart failure with the method of nourishing the heart and calming the mind,it was also confirmed that the improvement of TCM syndrome efficacy,cardiac function efficacy,LVEF,BNP,Minnesota quality of life score,and Lee's heart failure score in the treatment of chronic heart failure with the method of nourishing the heart and calming the mind was significantly better than that of conventional western medicine.