Study On Distribution And Clinical Features Of TCM Syndromes Of Cancer-Related Fatigue Caused By Primary Bronchial Lung Cancer

Objective: To analyze the distribution characteristics of TCM syndromes in patients with primary bronchial lung cancer CRF through cross-sectional studies,and to explore the distribution pattern of syndromes of CRF in patients with lung cancer;to analyze the clinical data,and to summarize CRF The general clinical characteristics of the patients provide basis for the intervention of the Chinese medicine system for lung cancer CRF.Methods: All 120 cases originated from the Respiratory Department of the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine from August 2018 to January2020.A database was created using Excel software,which was entered independently by the researchers and corrected by two researchers.Data statistics and analysis were performed using SPSS26.0 statistical software,with p <0.05 as the difference was statistically significant.Descriptive statistics including the mean and standard deviation are used to summarize the CRF status.The four diagnosis information of patients with lung cancer-related fatigue are quantified and the data are entered.The frequency and composition ratio are used to describe general information and TCM syndromes.The general clinical information was statistically analyzed,and its clinical characteristics were summarized.The four diagnosis data of patients with cancer-related fatigue were statistically analyzed using a cluster analysis method,and combined with professional knowledge and clinical practice,the CRF syndrome types and their distribution characteristics were summarized.Result:1.Results of general clinical data analysis in this study the degree of fatigue of patients with CRF in primary bronchial lung cancer was mainly moderate,followed by severe,and mildest.As the disease progresses,patients with different clinical pathological types will develop CRF.The distribution of patients with lung cancer CRF is more men than women.The primary age of CRF for primary bronchogenic lung cancer is 61 to 80 years old.There is no significant difference in the degree of CRF in different age groups(p> 0.05).Some CRF patients have a history of exposure to dust,harmful gases,chemical reagents,ionizing radiation,and other harmful substances.The study found that there was no significant difference in fatigue level between different pathological types and clinical stages(p> 0.05).Among the lung cancer CRF patients included in the study,the number of patients with lung adenocarcinoma was the largest.There was no significant difference in distribution among patients with different degrees of fatigue(p> 0.05).2.Physical and Chemical Examination,Piper Fatigue Scale and TCM Syndrome Study The study did not find different levels of fatigue in white blood cells(WBC),red blood cells(RBC),hemoglobin(HGB),platelets(PLT),albumin(ALB),plasma D-dimer(D-Dimer),C-reactive protein((CRP)significant differences in clinical indicators.CRF patients scored higher on the Behavior / Severity and Sensory Dimensions on the Piper Fatigue Scale.The yin deficiency syndrome,yang deficiency syndrome,blood stasis syndrome,phlegm-dampness syndrome,and cold-dampness syndrome have statistically significant differences among different fatigue levels(p <0.05),suggesting that changes in fatigue levels may be related to changes in the above syndromes.There was no significant difference in the distribution of different fatigue levels in the syndromes of qi stagnation syndrome,heat toxicity syndrome,qi deficiency syndrome,and blood deficiency syndrome(p> 0.05).Significant differences were found in the distribution of lung / large intestine,heart / small intestine,spleen / stomach syndromes with different degrees of fatigue(p <0.05),and liver /gallbladder,kidney / bladder syndromes had no distribution in different degrees of fatigue Significant difference(p> 0.05).3.Syndrome distribution characteristics of patients with CRF in primary bronchial lung cancer The statistical frequency of the patients in this study compared with the top 10 is: cough,fatigue,wheezing,sticky sputum,chord veins,tiredness,red tongue,yellow fur,thirst,and white phlegm.The syndromes with higher distribution of syndrome types include Qi deficiency syndrome,Yin deficiency syndrome,Blood deficiency syndrome,Blood stasis syndrome,Phlegm dampness syndrome,Qi stagnation syndrome,and Phlegm fever syndrome.CRF is related to the five internal organs,especially to the lungs and spleen,and to the heart,liver,and kidneys.By systematically clustering the high-frequency symptoms of patients included in the study,they were grouped into 4 types of dialectics: lung deficiency,spleen deficiency,phlegm-heat depression,lung deficiency;liver depression,spleen deficiency,blood stasis,and lung yin deficiency;Heart and spleen deficiency and Qi stagnation.Conclusion:1.Patients with lung cancer of different age groups and different pathological types will have CRF,most of them are elderly patients.2.Patients with lung cancer CRF had higher behavior / severity and sensory scores on the Piper fatigue scale.According to cluster analysis,the lung cancer CRF syndrome can be divided into four types: Lung spleen Qi deficiency phlegm heat depression lung.Liver depression,spleen deficiency,lung yin deficiency.Deficiency of lung and spleen Qi and deficiency of kidney essence.Heart and spleen deficiency and stagnation of blood stasis.The qi deficiency syndrome runs through the CRF,and the yin deficiency syndrome,yang deficiency syndrome,blood stasis syndrome,phlegm-dampness syndrome,and cold-dampness syndrome change with the progress of fatigue.The change is not significant.3.CRF of lung cancer is located in the lung,which is closely related to the heart,spleen,and liver.