| background:Vitreomacular interface disease refers to a class of diseases caused by age-related pathological changes in vitreoretinal interface of macular area,which is more common in the elderly population and is an important factor threatening the visual quality of the elderly.The current treatment method is not ideal for the restoration of visual function,so it is the key to the prevention and control of the vitreous macular interface to clarify its incidence and risk factors.Vitreous macular interface diseases mainly include epiretinal membranes(ERM),macular hole(MH),and vitreomacular traction syndrome(VTS).Among them,macular anterior membrane and macular hole are the most common.The subject selected the macular anterior membrane and macular hole as the main observation objects.The preliminary study of this topic found that: patients with epiretinal membranes and macular hole admitted to our hospital from 2011 to 2016 were more common in early postmenopausal women.It can be concluded whether sex hormones can be used as a risk factor for predicting the disease of the vitreomacular interface disease Objective:In this study,the contents of serum and vitreous estradiol and testosterone in patients with idiopathic macular membrane(IMEM)and idiopathic macular hole(IMH)in the experimental group were compared with those in the control group with rhegmatogenous retinal detachment group(RRD)to investigate the value of sex hormone metabolism in vitreous macular interface disease.Methods:From February 2019 to December 2019,107 patients(107 eyes)in the department of ophthalmology of the second affiliated hospital of nanchang university were hospitalized for vitrectomy,among which 37 patients(37 eyes)were in the IMEM group,13 males(13 eyes)and 24 females(24 eyes).There were 35 patients(35 eyes)in the IMH group,including 14 males(14 eyes)and 21 females(21 eyes).There were 35 patients(35 eyes)in the control group,including 15 males(15 eyes)and 20 females(20 eyes).All patients meeting the inclusion criteria were required to complete relevant specialist examinations before surgery,including slit lamp fundus examination,binocular b-ultrasound examination and Optical coherence tomography(OCT),and were confirmed by the same doctor in our hospital.Part of serum and vitreous body of all included patients were collected: elbow venous blood was extracted in the morning on an empty stomach;Extract the vitreous just before the vitreous cutting operation begins.The levels of E2 and T in serum and vitreous samples were determined by Enzyme-linked immunosorbent assay(ELISA).Results:The concentration of E2 in male serum(pg/ml)is: IMEM:18.59±3.68,IMH:18.24±4.8,control:17.41±4.17.The serum E2 level of male patients is: IMEM group >IMH group,> control group,and there is no statistically significant difference between the three groups or between the experimental group and the control group(P>0.05).The concentration of E2 in female serum(pg/ml)is:IMEM: 21.81±4.89,IMH: 22.4±5.45,control: 18.28±4.66.The serum E2 level of female is: IMH group >IMEM group > control group,and there are statistically significant differences between the three groups and between the experimental group and the control group(P < 0.05).The concentration of E2 in male vitreous samples(pg/ml)is:IMEM:10.27±3.25,IMH:11.12±3.67,control:9.11±3.56.The vitreous E2 level of male patients is: IMH group > IMEM group > control group.and there is no statistically significant difference between the three groups or between the experimental group and the control group(P>0.05).The concentration of E2 in female vitreous samples(pg/ml)is: IMEM:16.23±4.01 IMH:17.12±3.60,control:13.15±4.26.The vitreous E2 level of female patients is: IMH group > IMEM group > control group,and there are statistically significant differences between the three groups and between the experimental group and the control group(P < 0.05).The concentration of T in male serum(ng/ml)is: IMEM: 5.15±1.44,IMH:5.10±1.34,control:4.96±1.44,the serum T2 level of male patients is: IMEMgroup> IMH group> control group,and there is no statistically significant difference between the three groups or between the experimental group and the control group(P>0.05).The concentration of T in female serum(ng/ml)is: IMEM: 0.34±0.17,IMH:0.37±0.13,control: 0.41±0.13.The serum T2 level of female patients is: control group >IMH group > IMEM group,and there is no statistically significant difference between the three groups or between the experimental group and the control group(P>0.05).The concentration of T in male vitreous samples(ng/ml)is:IMEM:0.44±0.26,IMH:0.37±0.13,control:0.28±0.2.he vitreous T2 level of male patients is: IMEM group> IMH group> control group,and there is no statistically significant difference between the three groups or between the experimental group and the control group(P>0.05).The concentration of T in female vitreous samples(ng/ml)is: IMEM: 0.36±0.13,IMH: 0.34±0.11,control: 0.37±0.11.The vitreous T2 level of female patients is :control group > IMEM group > IMH group,and there is no statistically significant difference between the three groups or between the experimental group and the control group(P>0.05).Conclusion:High serum and vitreous estrogen levels may be risk factors for macular anterior membrane and macular hole disease in women. |
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