The Study On The Correlation Between PSF In Patients With Non-disabling Ischemic Stroke And 3-MST?H₂S In Plasma

Objective:To discuss the relativity between 3-MST?H₂S in plasma and post-stroke fatigue?PSF?in patients with non-disabling ischemic stroke.Methods:From October 2018 to May 2019,120 patients with non-disabling ischemic stroke who were hospitalized in the Department of Neurology,the First Affiliated Hospital of Shihezi University Medical College were selected as the case group.All patients were assessed according to Fatigue Severity Scale?FSS??Hamilton anxiety Scale?HAMA?and Hamilton Depression Scale?HAMD?,and were divided into post-stroke fatigue group and non-fatigue group.Collect the basic information of all the subjects,fasting venous blood was collected from the case group on the second day after admission,and 40 healthy patients who came to the hospital for physical examination during the same period were used as the control group.Enzyme linked immunology sorbent assay?ELISA?was used to determine the level of3-MST in plasma and the content of H₂S by microassay,and collect laboratory results.The differences of 3-MST and H₂S in plasma and the changes of each bioindicatorl were compared among the three groups,and the risk factors associated with PSF were analyzed.Results:?1?The 3-MST level in plasma?3.32±0.58 ng/mL?in the post-stroke fatigue group was significantly lower than that in the non-fatigue group?3.59±0.76 ng/mL?and the control group?4.66±1.04 ng/mL??P<0.01?,and the difference was statistically significant.?2?The H₂S level in plasma?8.09±3.45 umol/L?in the post-stroke fatigue group was significantly lower than that in the non-fatigue group?11.98±3.42 umol/L?and the control group?17.79±1.69 umol/L??P<0.01?,with statistically significant differences.?3?The high density lipoprotein level in plasma?1.14±0.24 mmol/L?in the post-stroke fatigue group was significantly lower than that in the non-fatigue group?1.28±0.24 mmol/L?and the control group?1.20±0.19mmol/L??P<0.01?,and the difference was statistically significant.?4?The total cholesterol level in plasma?4.31±0.55 mmol/L?in the post-stroke fatigue group was significantly higher than that in the non-fatigue group?3.75±0.63 mmol/L?and the control group?3.67±0.73 mmol/L??P<0.01?,with statistically significant differences.?5?The depression score?13.26±6.47?in the post-stroke fatigue group was significantly higher than that in the non-fatigue group?5.97±4.81??P<0.01?,with statistically significant differences.?6?Logistic regression results showed that the H₂S and HDL in plasma were negatively related with PSF?OR=0.753,0.049,P<0.05?;Total cholesterol and depression were positively related with PSF?OR=2.496,1.180,P<0.05?.Conclusions:1.Plasma levels of 3-MST?H₂S in the post-fatigue group of patients with non-disabling ischemic stroke were lower than those in the non-stroke fatigue group and the control group.2.TC in the post-fatigue group of patients with non-disabling ischemic stroke were higher than those in the non-stroke fatigue group and the control group.3.The depression scores in the post-fatigue group of patients with non-disabling ischemic stroke were higher than those in the non-stroke fatigue group.4.H₂S and HDL were negatively related with PSF.5.Total cholesterol and depression were positively related with PSF.