Correlation Between Salivary Cortisol Levels And Caries And Periodontal Disease In Patients With Depression

Objective: The test is designed to explore the relationship between salivary cortisol concentration and oral health in patients with depression,by comparing the differences between salivary cortisol concentration and oral status in patients with depression and non-depressed patients,to further analyze the relationship between salivary cortisol concentration and caries and periodontal disease in patients with depression,and the clinical guiding significance of salivary cortisol concentration as an indicator of oral health.Methods: 96 patients with depression were collected as experimental group,who were in the psychological department of the first Affiliated Hospital of Shihezi University Medical School from November 2018 to May 2019.Another 96 persons who had clinic in the first affiliated hospital of shihezi university medical school examination branch detection showed they were not depressed as control group.Collecting the demographic data and the saliva samples 2ml of every experment object between 8 am and 10 am.The method of enzyme-linked immunosorbent assay was used to detect the levels of salivary cortisol in samples.The Hamilton Depression Scale(HAMD-24)and the Oral Health Impact Scale(OHIP-14)were used to assess the mental state and oral health effects of the subjects,examination records oral status of all subjects.The relationship between the above factors and the concentration of salivary cortisol was analyzed by comparing the differences of the demographic data,oral status and oral health effects in the two groups.Results: The differences in gender composition ratio and smoking rates between two group have no statistically significance(P>0.05).There were significant differences in age,plaque index(PLI),bleeding index(BI),periodontal probing depth(PD),attachment loss(AL),simplified oral hygiene index(OHI-S,including dental calculus index and soft scale index),dental caries loss(DMFS)and OHIP-14 scores between the two groups(P<0.05).The level of salivary cortisol in patients with depression was significantly higher than that in the non-depressed population(P<0.05).The level of salivary cortisol in women was higher than that in men in depression group,the difference was statistically significant(P<0.05).The level of salivary cortisol has no significant difference between women and men in non-depressed population(P>0.05).The level of salivary cortisol in depression group increased significantly with positive correlation with age,sex,smoking history,PD,dental stone index(CI)(r>0,P<0.05).The level of salivary cortisol in non-depression group increased significantly with positive correlation with age,sex,smoking history,PD,AL(r>0,P<0.05).After controlling for other confounding factors the score was only associated with the level of salivary cortisol,which was at an increased risk 35.1% for each unit of increase(OR=1.351,P<0.05).Thescores of OHIP-14 were significantly with positive correlation with depression,periodontal status and DMFS(r>0,P<0.05).Conclusion: 1.Periodontal status of patients with depression were associated with changes in the level of salivary cortisol,and no association with caries.2.Depression patients with poor oral condition,oral quality of life was decreased,depression patients were more prone to dental caries and periodontal disease than no-depression.