The Clinical Features Of Interstitial Lung Disease Combined With Lung Cancer

Background:Interstitial lung disease with lung cancer(interstitial lung disease combined with lung cancer,ILD-LC)is one of the more common diseases in respiratory department.in recent years,the incidence and mortality rate have increased year by year.some patients have been in the advanced stage of the disease once diagnosed,which brings great difficulties to clinical treatment.ILD-LC early detection,early intervention has become particularly important.Objective:To collect ILD-LC clinical data,summarize the clinical characteristics of ILD-LC patients,improve clinicians’ understanding of ILD-LC,reduce missed diagnosis and misdiagnosis,and promote early diagnosis and treatment of ILD-LC patients with a view to improving the quality of life of patients and prolonging the life cycle of patients.Method:To review and analyze the clinical data of 151 inpatients,including 49 ILD-LC patients,51 patients with simple lung cancer(lung cancer,LC)and 51 patients with interstitial lung disease(interstitial lung disease,ILD),treated in the second hospital of Jilin University from January 2016 to December 2019 were reviewed and analyzed.The medical records of three groups were statistically analyzed,including sex,age,smoking history,clinical symptoms and signs,blood gas analysis,pulmonary function,pulmonary artery pressure force,imaging examination,serum tumor marker level treatment methods,etc.statistical analysis using SPSS22.Results:1.LD-LC group was dominant in male ratio,age and smoking index.significant difference compared with ILD group(P<0.05).2.ILD-LC group and ILD group compared hemoptysis symptoms more obvious,relatively less dyspnea,pestle finger proportion is more,ILD-LC group compared with the LC group patients hemoptysis less,double lung burst sound proportion is higher,the difference is statistically significant(P<0.05).3.The CA125、Cyfra21-1、CA199、CEA、CA153 level of the ILD-LC group was 54.05(28.58,143.35)U/ml,4.65(3.17,9.63)ng/ml,25.72(5.59,501.53)U/ml,8.38(4.14,19.88)ng/ml,29.25(15.68,52.15)U/ml which was significantly higher than that of the ILD group(P<0.05).4.The incidence of pulmonary hypertension was 57% in the ILD-LC group,35% in the LC group,and significantly higher in the ILD-LC group(P<0.05).5.Small cell carcinoma 12(24.5%),squamous cell carcinoma 11(22.4%),adenocarc-inoma 25(51%)and large cell carcinoma 1(2.1%)in ILD-LC group.small cell 11(21.6%)squamous cell carcinoma 11(21.6%)and adenocarcinoma 29(56.8%)in the LC group.there was no difference in pathological distribution between the two groups,but the proportion of adenocarcinoma was the highest in the two groups.6.The PO2、FVC%pre、DLCO of the ILD-LC group were 71.6±15.099,76.60±11.88,39.75±17.71,which were significantly lower than those of the LC group(P<0.05).7.The pathological diagnosis of lung cancer in ILD-LC group was confirmed by bronchoscopic biopsy,TBLB or EBUS-TBNA in 29 cases,percutaneous lung puncture in 6 cases,supraclavicular lymph node puncture or biopsy in 6 cases,pleural effusion exfoliated cells in 5 cases,and surgical diagnosis in 2 cases.IV period 19,IIIa 1,IIIb 13,IIIc 10,IIb 1,2 cases,Ia2 1 case Ib 1 case.8.ILD-LC group of tumors mainly occurred in 29 regional lesion areas with severe subpleural fibrosis,18 in the upper lobe,26 in the lower lobe and 4 in the middle lobe.9.ILD-LC surgical resection was performed in 5 cases.17 patients underwent chemotherapy,7 targeted therapy and 1 immunotherapy.7 deaths in hospital.Conclusions:1.Elderly,male,smoking,are risk factors for LC in patients with pulmonary interstitial fibrosis.2.the expression of ILD-LC tumor markers is usually parallel to the onset of tumor CA199、CA125、Cyfra21-1、CEA can be used as a basis for ILD-LC assisted diagnosis.3.ILD-LC lesions are more common in the lower lobe,peripheral cancer,adenocarcinoma is more common.