| Objective:This present study aimed to explore the clinical relationship between Helicobacter pylori(Hp)and hepatobiliary and pancreatic diseases,so as to provide a clinical insight into the pathogenic mechanism of hepatobiliary and pancreatic diseases induced by Hp infection.Methods:A total of 772 patients who were admitted to the second department of the First Hospital of Jilin University from January 2017 to January 2020 due to liver diseases were randomly selected,including 109 patients with non-alcoholic fatty liver,212 patients with chronic viral hepatitis B,124 patients with chronic viral hepatitis C,276 patients with post-hepatic cirrhosis,and 34 patients with primary biliary cirrhosis,86 patients with liver cancer,179 patients with cirrhosis and upper gastrointestinal bleeding after hepatitis,and 114 patients with hepatic encephalopathy.There were some patients above with more than two different types of liver disease simultaneously.There were 100 patients with acute pancreatitis and 178 patients with gallbladder disease(including 68 patients with simple cholecystitis,35 patients with simple gallbladder stones,and 75 patients with stone cholecystitis).A total of 150patients(control group)were enrolled randomly from the Physical Examination Center of the First Hospital of Jilin University.Patients' demographic data including gender,age and Hp test results,and the main laboratory indicators of patients with chronic liver disease,such as total bilirubin,albumin,prothrombin prolonged time,ascites,Child-Pugh classification,blood ammonia value in patients with hepatic encephalopathy were recorded.To investigate the relationship between Hp and the diseases above,chi-square(x ^ 2)test was used for categorical data,independentsample T test for continuous data,if data meet the normal distribution,and the U test for the data not in accordance with the normal distribution.Results:(1)Among the 150 control groups,there were 61 Hp-negative patients,32 were males and 29 were females,the male-female ratio of 1.10:1,patients' age was 52(46,52.5)years old.There were 89 Hp-positive patients,49 were males and 40 were females,the male-female ratio was 1.23:1,and the patients' age was 57(51,63.5)years old.There was no statistically significant difference regarding gender between the two groups(P> 0.05),whereas there was statistically significant difference with regard to age between the two groups(P <0.05).Among the 1050 diseased group,there were 336 Hp-negative patients,183 were males and 153 were females.The male-female ratio was 1.20:1,and the age was 50.0(56.0,65.0)years old,There was no statistically significant difference regarding gender between the two groups(P>0.05),whereas there was statistically significant difference with regard to age between the two groups(P <0.05).(2)The positive rate of Hp in the control group was 59.3%,and in the diseased group was 68%,and the positive rate of Hp in the control group was significantly lower than that in the affected group,with a significant statistical difference(P<0.05).(3)The proportion of Hp positive patients in the control group was 59.3%.The proportion of Hp positive patients in the primary biliary cirrhosis group,non-alcoholic fatty liver group,the simple cholecystitis group,the simple gallbladder stone group,and the acute pancreatitis group was 47.1%,67.9%,66.2%,54.3% and 56%separately,which were not statistically different from the control group(P> 0.05).What's more,the proportion of Hp-positive in the liver cancer group,the portal hypertension group,the stone cholecystitis group,the chronic hepatitis C group,the chronic hepatitis B group,the liver cirrhosis group,the hepatic encephalopathy group,and the upper gastrointestinal bleeding group was 77.9%,74.9%,76%,70.2%,68.4%,71.7%,71.9%,and 73.2%,respectively,which were significantly different fromthe control group(P <0.05).(4)In patients with chronic liver disease,the total bilirubin value and the prothrombin prolongation time were higher in the Hp-positive group,whereas the albumin value in the Hp-positive group was lower.The difference was statistically significant(P <0.05).(5)In terms of the Child-Pugh classification,the proportion of Child C grade in Hp-positive group was 19.8%,whereas the proportion of Child C grade of liver function in Hp-negative group was 0.8%(P <0.05).There was a statistically significant difference in the severity of ascites between the Hp-positive group and the negative group(P <0.05).(6)The incidence of ulcer bleeding in the Hp-positive group was higher than that in the Hp-negative group in patients with cirrhosis combined with upper gastrointestinal bleeding after hepatitis,with a statistically significant difference between the two groups(P <0.05).However,there was no statistically significant difference in the incidence of rupture of gastric varices and other gastritis between the two groups(P> 0.05).(7)In patients with hepatic encephalopathy,the blood ammonia value of the Hp-positive group was higher than that of the Hp-negative group(P <0.05).Nevertheless,there was no statistically significant difference in the severity of hepatic encephalopathy between the two groups(P> 0.05).(8)In patients with chronic liver disease,the incidence of portal hypertension in the Hp-positive group was higher,and the difference between the two groups was statistically significant(P <0.05).(9)In patients with calculus cholecystitis,there was no significant difference in terms of the length of hospitalization and the total number of white blood cells between the Hp-positive group and the negative group(P> 0.05).Conclusions:(1)Hp infection may was related to age(P <0.05),but not to gender(P> 0.05).(2)Hp infection may was associated with chronic viral hepatitis B,chronic viral hepatitis C,cirrhosis after hepatitis,liver cancer,upper gastrointestinal bleeding,hepatic encephalopathy,portal hypertension,and calculus cholecystitis(P <0.05).However,Hp infection may was not associated with primary biliary cirrhosis,non-alcoholic fatty liver,simple cholecystitis,simple gallbladder stones,and acute pancreatitis(P> 0.05).(3)Hp infection may was related to total bilirubin value,albumin index value,prolonged prothrombin value,blood ammonia value,severity of ascites,Child-Pugh grade of liver function,and occurrence of ulcerative bleeding(P <0.05).However,Hp infection may was not related to the severity of hepatic encephalopathy,the occurrence of varicose vein rupture and other gastritis,and the length of hospitalization and white blood cell count of patients with calculus cholecystitis(P>0.05). |
PDF Full Text Request