Mindfulness-based Relapse Intervention On Male Patients With Amphetamine-type Stimulants Use Disorders:An EEG-functional Connectivity Study

Objectives:To test the efficacy of mindfulness-based relapse intervention on male patients with amphetamine-types stimulants use disorders,and invest its mechanism using EEG-functional connectivity.Methods:40 male participants from a compulsory rehabilitation center in Shnaghai who have amphetamine-types stimulants use disorders are enrolled in this randomized controlled trial(RCT).They were randomly divided into either the intervention group(n=20)or control group(n=20).The intervention group received 10 days,2-hour per day,mindfulness-based relapse prevention intervention,while the control group attend normal compulsory addiction treatment in the institution.Self-rating depression scale(SDS),Self-rating anxiety scale(SAS),Emotion Regulation Questionnaire(ERQ),Perceived Stress Scale(PSS),Barratt Impulsiveness Scale(BIS),Mindfulness Attention Awareness Scale(MAAS),Self-rating craving scale,CogState,and resting EEG were assessed before and after the intervention.Results:1.40 participants enter the before assessment while 39 entered the after one.Between-group significant differences were not found in general information and drug use histories(p>0.05),except the age(participants in the intervention group were younger than those in the control group,p<0.05).3.a significant increase in function connectivity of frontal cortex were found in the intervention group after the intervention(p<0.05).3.No significant differences were found in depression,anxiety,perceived stress,impulsiveness,craving and Cogstate before and after the intervention(p>0.05).While the mindfulness scores in the intervention group were significantly higher than the control group(p<0.05);the repeated measures analysis of variance showed the two group in time_*effect are significant different(p<0.05).Conclusions:The mindfulness-based relapse intervention is effective in improving the mindfulness attention awareness and increasing the functional connectivity of frontal cortex for people with amphetamine-type stimulants.