| Purpose:Retrospective analysis of the correlation between ulcerative colitis?UC?and serum total bilirubin?STB?,uric acid?SUA?,cholinesterase?CHE?and Ca2+Methods:Collect the case data of our hospital's gastroenterology department from January2010 to May 2019.A total of 361 patients with complete active ulcerative colitis,and111 adults who underwent normal physical examination at the medical examination center of our hospital as Control group.According to the clinical data and biochemical indicators of patients with UC,both groups excluded a history of diseases known to affect the levels of bilirubin,uric acid,cholinesterase,and calcium ions,and excluded those aged <18 years.The case group was divided into three subgroups according to severity,82 cases were mild,228 cases were moderate,and 51 cases were severe.111 cases in the control group.The levels of serum bilirubin?Bilirubin?,uric acid?SUA?,cholinesterase?CHE?and Ca2 + were compared between the four groups.Perform multi-factor regression analysis on indicators with significant differences and use ROC curve to predict the diagnostic value of the above biochemical indicators for UC?Result:1.There were 111 people in the control group,including 43 males?38.74%?and68 females?61.26%?.In the ulcerative colitis group,361 cases,mild 82 cases?22.71%?,moderate 228 cases?63.16%?,and severe 51 cases?14.13%?.44 cases were mild male?53.66%?,38 were female?46.34%?,122 were male?53.51%?,106 were female?46.49%?,23 were male?45.10%?,28 were female?54.90?%).The Pearson chi-square test with multiple sample rates for the sex ratio of the groups showed no statistically significant difference between the four groups?P> 0.05?.The age of the control group was 52?45,60?,the age of mild UC was 54.50?41.75,60?,and the moderate UC Age 47?36,56?,severe UC age 46.5?32,58?,no statistically significantdifference in age?P> 0.05?.2.Mild UC total bilirubin 12?9.37,18.50?,moderate UC total bilirubin 12?9.01,15.78?,severe UC total bilirubin 8.54?6.71,12.00?,control group total bilirubin 11.89?9.06,16.90?.After the Kruskal-Wallis H test,there were significant differences?H = 19.831,P <0.05?.Pairwise comparison of independent samples resulted in mild and comparative control P = 1,mild and moderate comparison P = 1,moderate and control comparison P = 1,severe and mild comparison P = 0.000001,severe and moderate Degree comparison P = 0.000012,severe comparison with control group P = 0.001,the difference was statistically significant.3.Mild UC direct bilirubin 2.56?1.87,3.94?.Moderate direct bilirubin 3.19?2.04,4.92?,severe direct bilirubin 4.10?1.90,5.00?,control group direct bilirubin2.01?1.56,3.13?.After the Kruskal-Wallis H test,there were significant differences?H = 43.03,P <0.05??see Table 1.1?.Pairwise comparison of independent samples resulted in mild to moderate comparison P = 0.091,mild to severe comparison P =0.315,mild to comparison group P = 0.029,moderate to severe comparison P = 1,moderate to control Group comparison P = 0.000017,there is a significant difference,severe comparison with the control group P = 0.00002,there is a significant difference.4.Mild UC patients with indirect bilirubin 9.55?6.77,14.48?,moderate UC patients with indirect bilirubin 8.50?6.14,12.51?,severe UC patients with indirect bilirubin 5.20?4.27,7.40?,control group 9.79?7.5,13.87?.After the Kruskal-Wallis H test,there were significant differences?H = 48.010,P <0.05??see Table 1.1?.Pairwise comparisons of independent samples resulted in mild and moderate comparisons P = 0.707,mild comparison with the control group P = 1,moderate comparison with the control group P = 1,mild comparison with severe P <0.05,moderate comparison with Severe comparison P is less than 0.05,and severe comparison with the control group P is less than 0.05,the difference is statistically significant.5.Cholinesterase 8977?7432.25,10695.25?in patients with mild UC,cholinesterase 7292.50?5920,8855.75?in patients with moderate UC,cholinesterase3912?2319,5680?in patients with severe UC,choline in the control group Esterase9696?8592,11050?.After the Kruskal-Wallis H test,there were significant differences?H = 164.695,P <0.05??see Table 1.1?.Pairwise comparisons of independent samples were slightly compared with the control group P = 0.145,the other groups compared cholinesterase levels P <0.05,there was a statistical difference.6.Uric acid 287.45?246.66,379.78?in patients with mild UC,278.8?215.20,340.80?uric acid in patients with moderate UC,193.9?154.28,236.19?uric acid in patients with severe UC,298.69?262.97,357.28?uric acid in the control group.After the Kruskal-Wallis H test,there were significant differences?H = 122.869,P<0.05??see Table 1.1?.Pairwise comparison of independent samples resulted in mild and moderate comparison P = 0.542,mild comparison with control group P = 1,moderate comparison with control group P = 0.94,severe comparison with the remaining three groups P <0.05,with statistics Learn the differences.7.The average value of calcium ion in patients with mild UC?2.29 ± 0.132?,calcium ion in patients with moderate UC?2.25 ± 0.131?,calcium ion in patients with severe UC?2.05 ± 0.15?,and calcium ion in control group?2.36 ± 0.11?.In the four groups,the multi-sample Levene test showed that P = 0.003,the variance was uneven,P <0.05 after correction,and there was a statistical difference?T = 15.024,P<0.05?.After Kruskal-Wallis H test,the results were: Moderate comparison P = 0.188,mild to severe comparison P <0.05,mild to severe control group P = 0.001,moderate to severe comparison P <0.05,moderate to severe control group P <0.05,severe to severe control group comparison P <0.05.8.After Spearman correlation analysis of UC and total bilirubin,there was a negative correlation between the two variables?r =-0.117,p <0.05?.After Spearman correlation analysis of UC and direct bilirubin,there was a positive correlation between the two variables?r = 0.284,p < 0.05?,after Spearman correlation analysis between UC and indirect bilirubin,there was a negative correlation between the two variables?r =-0.267,p <0.05?,and after Spearman correlation analysis between UC and cholinesterase,there was a negative correlation between the two variables?R =-0.573,p <0.05?,after Spearman correlation analysis of UC and uric acid,the twovariables were negatively correlated?r =-0.334,p <0.05?,after Spearman correlation analysis of UC and calcium ion,the two variables were negative Correlation?r =-0.478,p <0.05?.9.First perform single factor logistic regression,and set a = 0.1.Total bilirubin P = 0.491,direct bilirubin P <0.05,indirect bilirubin P = 0.01,cholinesterase P <0.05,uric acid P = 0.005,calcium ion P <0.05,sex P = 0.002,age P = 0.002,the above statistically significant factors were substituted into the binary logistic regression analysis.The results showed that age was negatively correlated with ulcerative colitis,which was a protective factor for ulcerative colitis?OR = 0.974,p = 0.025?.Compared with male patients,females are protective factors for ulcerative colitis?OR= 0.317,p = 0.01?.Direct bilirubin is positively correlated with ulcerative colitis.With the increase of direct bilirubin,the risk of ulcerative colitis increases.Direct bilirubin is an independent risk factor for ulcerative colitis?OR = 0.941,p <0.05?.Indirect bilirubin is negatively correlated with ulcerative colitis and is a protective factor for ulcerative colitis?OR = 0.858,p = 0.03?.Uric acid is negatively correlated with ulcerative colitis and is a protective factor for ulcerative colitis?OR = 0.99,p<0.05?,calcium ion is negatively correlated with ulcerative colitis,which is a protective factor for ulcerative colitis?OR = 0.003,p <0.05?.10.Using Medcalc19.0 to make ROC chart,in addition to the total bilirubin,the AUC?area?under the curve of the factors of direct bilirubin,indirect bilirubin,cholinesterase,uric acid,and calcium ions are 0.671,0.612,0.761,0.607,0.77,the significance is?p <0.05?.Cholinesterase cutoff value 8242,sensitivity 63.71%,specificity 81.48%.Calcium ion cutoff value is 2.27,sensitivity is 59.72%,and specificity is 83.33%.Indirect bilirubin cutoff value is 6.86,sensitivity is 36.57%,and specificity is 87.04%.Uric acid cut-off value is 262,sensitivity is 45.58%,and specificity is 76.92%.The cutoff value of direct bilirubin is 3.68,the sensitivity is43.21%,and the specificity is 90.74%.The cut-off value of total bilirubin was 8.4,the sensitivity was 22.99%,and the specificity was 87.04%.After the ROC area test of cholinesterase and calcium ions was performed,there was no statistical difference?P= 0.8032?.After that,there were significant differences?p <0.05?.After indirectbilirubin and direct bilirubin ROC area test,there was no statistical difference?P =0.3712?.Direct bilirubin and indirect bilirubin had significant differences compared with total bilirubin?p <0.05?.Uric acid was significantly different from cholinesterase and calcium ions?p <0.05?.There was no statistical difference between uric acid and direct bilirubin?P = 0.715?,and no significant difference from indirect bilirubin?P =0.754?.There was no statistical difference between uric acid and total bilirubin?P =0.4346?.After performing SPSS binary logistic regression on the above five diagnostically valuable factors,after the ROC chart,the combined AUC?area?was0.831,the sensitivity was 64.72%,and the specificity was 94.44%.Conclusion:1.Total bilirubin,direct bilirubin,indirect bilirubin,uric acid,cholinesterase and calcium ions may be protective factors of UC,indirect bilirubin has a significant protective effect on UC,and uric acid may have a protective effect on UC It is greater than indirect bilirubin and should be supplemented when the body is low in calcium.2.The value of direct bilirubin and indirect bilirubin in predicting UC is relatively small,and the cutoff values are 3.68 ? mol / L and 6.86 ? mol / L,respectively.3.Calcium ion and cholinesterase can be used as a reference index to evaluate the severity of UC.Both predict the diagnostic value of UC is equal and higher than indirect bilirubin.The cutoff values were 2.27 mmol / L and 8242 U / L,respectively.4.Women's own structural characteristics are not prone to UC.The older you are,the lower your risk of UC. |
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