| Objective: This study discussed the distribution characteristics and influence factors of the vaginal microecology,and analyzed the results of vaginal microecology and questionnaire of 303 patients in our hospital,in order to provide advice for the clinical treatment of vaginitis.Research Methodology: We conducted a questionnaire survey on patients and recorded the results of their vaginal microecological report,who went to the Second Hospital of Jilin University for a vaginal microecological examination from December 2018 to December 2019.A total of 303 valid questionnaires were collected.We analyzed the vaginal microecology report results and questionnaire results of these 303 patients.The differences in the constituent ratios of various types of vaginal microecological disorders and normal flora were compared.Logistic regression analysis was used to analyze the relevant influencing factors of various types of vaginitis: age,income,history of vaginal birth in 3 years,time of first sexual life,the number of sexual partners,intrauterine device,high-risk HPV infection,gynecological lotion cleaning of vulva,etc.Finally,we compared the composition ratio of high-risk HPV infection positive group and negative group in different influencing factors in order to provide recommendations for the clinical diagnosis and treatment of vaginitis and high-risk HPV infection.This study used SPSS 23.0 software for statistical analysis.Normally distribute continuous variables are expressed as mean ± SD.Measurement data for skewed distributions are expressed as median ± quartile intervals.Classified data is described by frequency(percentage).Comparisons between groups of continuous variables were performed using independent sample t-tests or analysis of variance.A comparison between the two categorical variables or rates was made using a chi-square test.The main influencing factors were screened by binary logistic regression.Results:1.The average age of 303 patients was 36.44 ± 11.33,mainly concentrated in 31-40 age group.There were 96(31.7%)patients in the 31-40 age group and 95(31.4%)in the 21-30 age group.90.8% patients were p H> 4.5;positive rate of leukocyte esterase was 96%;negative rate of sialidase was 84.8%;positive rate of hydrogen peroxide was 92.1%.2.The composition ratio of patients in the BV group in autumn and winter was higher than that in normal group,and in BV group,the proportion in the autumn was the highest(60%).The proportion of BV patients in following cases was higher than normal patients,infecting high-risk HPV,vulvar / vaginal itching,living in rural areas,high school education and below,the average income of a family was less than 2,000 yuan monthly,the age of first time?25 years old,non-menstrual using pads,replacement of sanitary napkins?3 times daily,no using and occasional using condoms,no gynecological lotion to clean the vulva.The difference was statistically significant(P <0.05).The dominant bacteria in the BV group were all G-b(s);the positive rates of hydrogen peroxide,sialidase,and leukocyte esterase were all 100%.PH value in BV group was higher than control group.3.The BV intermediate group has the highest composition ratio(40%)in the 41-50 age group.The proportion of patients with BV intermediate in the following cases was higher than the normal group,the number of sexual partners?2,high-risk HPV infection,vulvar / vaginal itching,feeling increased secretions / odors,living in rural areas,high school education and below,household per capita income below 2000 monthly,having an IUD,not using and occasionally using condom.The difference was statistically significant(P <0.05).4.The proportion of VVC patients occurred in autumn was the highest(68.4%),and the proportion of VVC occurred in autumn and winter was higher than the normal group.78.9% of patients with VVC have vulvar / vaginal itching.The proportion of VVC patients in the following cases was higher than the normal group,no use and occasionally use condoms and no use gynecological lotions cleaning the vulva,the difference was statistically significant(P <0.05).5.The proportion of abnormal bacterial flora was highest in the group?51 age group(31.3%),followed by the group of 41-50 years old(28.1%),which were higher than the normal group.The proportion of patients with abnormal vaginal flora in autumn was 50%,and the proportion of patients in autumn and winter was higher than that in the normal group.Among patients with abnormal vaginal flora,53.1% had symptoms of vulvar / vaginal pruritus,and 81.3% had increased secretions and odors.The proportion of flora abnormality patients in the following cases was higher than the normal group,living in rural areas,high school education and below,per capita monthly household income below 2000,non-menstrual use of pads,replacement of sanitary napkins during menstruation?3 times daily,no and occasional use of condoms,no gynecology lotions cleaning the vulva,the difference was statistically significant(P <0.05).6.In the mixed infection group,the proportion of autumn was 70%.The proportion of patients with mixed infection in autumn and winter was higher than that in the normal group.The proportion of mixed infection patients in the following cases was higher than the normal group,number of sexual partners?2,high-risk HPV infection,vulvar / vaginal itching,increased secretion / odor,per capita household income below 3,000 yuan monthly,high school education and below,the age of first time?25 years old,using pads during non-menstruation,no using and occasional using condoms,no gynecological lotions cleaning the vulva,using IUD,the difference was statistically significant(P <0.05).7.High income(OR=0.309,95% CI 0.132 ~ 0.721)was a protective factor for BV.Sexual life frequency(OR=5.494,95% CI 1.913 ~ 15.780)and number of sexual partners(OR=4.017,95% CI 1.179 ~ 13.690)were risk factors for BV.8.The number of sexual partners(OR=9.892,95% CI 1.729 ~ 56.604)and high-risk HPV infection(OR=8.009,95% CI 1.486 ~ 43.166)were risk factors for BV intermediate.9.The use of condom during sexual life(OR=0.540,95% CI 0.332 ~ 0.876)were the protective factors of VVC.The risk of VVC in autumn is 6.059 times than that in spring.Autumn(OR=6.059,95%CI 1.098~33.441),Vulvar / vaginal itching(OR= 4.284,95% CI 1.385 ~13.256),the age of first time(OR=2.161,95% CI 1.132 ~ 4.125),sexual life frequency(OR=4.328,95% CI 2.096 ~ 8.937)were risk factors for VVC.10.Sexual life frequency(OR=4.038,95% CI 1.275 ~ 12.786),feeling increased secretions / odors(OR=35.741,95% CI 3.340 ~ 382.501),vulvar/vaginal itching(OR= 101.540,95% CI 7.587 ~ 1359.021)were risk factors for mixed infections.11.Compared with patients in the high-risk HPV-negative group,dominant bacteria abnormality,hydrogen peroxide,sialidase,acetylglucosidase,Nugent> 3 points,BV,BV intermediate,TV and mixed infection,the difference was statistically significant(P <0.05).Conclusion: 1.Compared with the control group,the abnormal vaginal microflora was raised in the autumn and winter,as well as BV,VVC and the mixed infections.2.Women are prone to intravaginal infections,who has high-risk HPV infection,lower income,two or more sexual partners,high frequency of sexual life,feeling increased secretions or odors,vulvar or vaginal itching,and younger age at the beginning of sexual life.Using condoms and washing vulva with gynecological lotions can reduce the possibility of intravaginal infection.3.High-risk HPV infection is closely related to vaginal microecological disorders.. |
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