The Comparative Study On The Premature CAD And Mature CAD

Background: Premature coronary artery disease(PCAD)seems to increase,particularly in developing countries.Given the lack of such studies in the country,this study compares,differentiate and examines the prevalence,associated risk factor and coronary angiography profile among PCAD and Matured Coronary Artery Disease(MCAD)patients hospitalized at Zhongda Hospital in Nanjing,China.Methods: We examined in this case-control study,a total of 568 clinically diagnosed CAD patients who underwent coronary angiography(CAG)at Zhongda Hospital,Gulou district,Nanjing in a period from 2009-2015.Patients were divided into PCAD(male <55 years and female <65 years)and mature coronary artery disease(MCAD).Results: There were significant differences in gender,education level,family history of coronary heart disease,family history of hypertension,platelet,high-density lipoprotein,and apolipoprotein A between premature and mature CAD(P<0.05).Hypertension,diabetes is significantly higher than among MCAD patients compared to the PCAD patients;also the degree of coronary stenosis is severe,and more prone to multi-vessel disease.In logistic regression model,the patient with diabetes mellitus(OR=2.830,95%CI: 1.455~5.504),hypertension(OR=1.763,95%CI: 1.026,3.028)and drinking(OR=2.007,95%CI: 1.203,3.348)were associated with increased odds of having PCAD compared with mature CAD.In other words,people with these characteristics are at greater risk of developing coronary disease earlier.Conclusion: This study concludes that the rate of premature CAD in the city is rising at an alarming rate and that it‘s mostly related to the accumulation of cardiovascular risk factors such as hypertension,diabetes and alcohol consumption.