Correlation Study Between Different Obesity Indices And Various Stages Of Parkinson's Disease

Background: Parkinson's disease(PD)is a neurodegenerative disorder that is prevalent among old aged people.The incidence is higher among patients with higher body mass index(BMI),Patients with Parkinson's disease at the time of diagnosis have an above-normal BMI which goes below normal as the disease progresses.They also have a high lipid panel level at the time of diagnosis compared to as the disease progresses.Objective: To establish a correlation between obesity,lifestyles,genetics,metabolic syndrome,and the risks of Parkinson's disease(PD).To determine the cause for a decrease in high lipid levels as the disease progresses.To determine if Physical activity could reduce the risk of Parkinson's disease.Methods: In this study,a total of 349 outpatients and inpatients with Parkinson's disease were selected from the People's Hospital affiliated to Jiangsu University between the period of January 01,2014,to December 31,2018.Seventy-four inpatients with non-cerebrovascular illnesses in the same period were selected as the control group.According to Hoehn-Yahr grade,Parkinson's patients were divided into early-stage(1 ~ 2 grade),middle stage(2.5 ~3 grade),and late-stage(4 ~ 5 grade).The height,weight,waist and hip circumference,total cholesterol(TC),Total Glycerol(TG),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)were measured and recorded.The relationship between the severity of Parkinson's disease and blood lipids was also evaluated.Results: The body mass index of patients with Parkinson's disease was higher than that of the control group at the early stage of the disease,but lower than that of the control group in the late stage,and the level of blood lipid in the patients with early Parkinson's disease was significantly higher than that in the healthy control group and patients with advanced.Parkinson's disease,especially in TG.The waist circumference and hip circumference of the patients with early Parkinson's disease were higher than those in the control group,but there was no statistical difference.Conclusions: Metabolic syndromes may disrupt the dopaminergic pathway and also affects the medication used in treating Parkinson's disease(PD)and decreasing the chances of proper PD management.According to our study,we find that i)Obesity may increase the prevalence of Parkinson's disease.ii)The body mass index of patients with Parkinson's disease shows two-way changes in different periods.iii)the body mass index is higher,and cholesterol is more elevated in the early stage of Parkinson's disease.Attention should be paid to these metabolic syndromes.Neurologists should work hand in hand with endocrinologists and nutritionists to follow up on PD patients for proper management and prognosis.