Correlation Analysis Of Bone Mineral Density And C-peptide Level In Elderly Tibetan And Han Male Patients With T2DM In Qinghai Province

Objective:To explore the relationship between bone mineral density(BMD)and C-peptide levels in elderly men with type 2 diabetes(T2DM)in Tibetan and Han ethnic groups,with a view to providing a reference for the clinical prevention and treatment of DOP in Tibetan and Han elderly male populations in Qinghai.Methods: From November 2017 to November 2019,the endocrinology department of the affiliated hospital of QingHai University was selected from 89 Tibetans and 140 Hans who were T2 DM men and women who met the inclusion and exclusion criteria.According to WHO's diagnostic criteria for T value obtained from BMD,the study subjects were divided into normal bone mass group,low bone mass group,and osteoporosis(OP)group.General data were collected according to BMD value,and fasting C-peptide(FCP),2hC peptide(2hCP),bone mineral density(BMD)value and biochemical indicators after meals,and the relationship between BMD value and serum C peptide level and related clinical biochemical indicators were analyzed.Data analysis was performed using spss21.0 statistical software.Results:1.The comparison of related indexes between the Tibetan and Han T2 DM patients showed that there was no statistically significant difference in the BMD between the Tibetan and Han people at the same level of the lumbar spine,femoral neck,hip,and left forearm 1/3(P> 0.05).2.Han T2 DM patients were divided into three groups according to BMD.The OP group had lower BMI,FCP,2hCP,and HOMA-HBCI than the low bone mass group and normal bone mass group;the OP group FPG and ALP were higher than the low bone mass group and bone mass In the normal group,the difference was statistically significant(P <0.05).3.Tibetan T2 DM patients are divided into three groups according to MBD.The OP group has lower BMI,FCP,Ca,HOMA-HBCI than the low bone mass group and normal bone mass group;the OP group has 2hPG higher than the low bone mass group and normal bone mass group;FCP in OP group and low bone mass group was lower than that in normal bone mass group,the difference was statistically significant(P <0.05).4.Analysis of factors influencing OP caused by elderly Tibetan male T2 DM patients: The results showed that FPG and Ca did not enter the regression model,while FCP,2hCP,HOMA-HBCI and BMI were still statistically significant.The risk of OP increases with the decrease of FCP,2hCP,HOMA-HBCI,BMI,which is the protective factor of OP.5.Analysis of factors influencing OP caused by elderly T2 DM patients in Han nationality: The results showed that HOMA-HBCI,ALP,and 2hCP did not enter the regression model,while FCP,BMI,and FPG were still statistically significant.The risk of OP increases with decreasing FCP and BMI,and increases with increasing FPG.FCP and BMI are protective factors of OP,and FPG is a risk factor of OP.Conclusions:1.Among elderly male T2 DM patients in Qinghai,there is no difference in BMD between Tibetan and Han patients.No matter Tibetan or Han people,serum C-peptide levels are related to BMD,and the risk of OP increases with the decrease of C-peptide levels.2.BMD,BMI and HOMA-HBCI are closely related to Tibetan elderly T2 DM patients in Qinghai region;and the lower the HOMA-HBCI and BMI,the higher the risk of OP,which is the protective factor of OP.3.BMD is closely related to BMI and FPG in elderly T2 DM patients of Han nationality in Qinghai;the risk of op increases with the decrease of BMI and increases with the increase of FPG.BMI is the protective factor of OP,and FPG is the risk factor of OP.