| Objective:To investigate the relationship between 24-hour urinary potassium level and kidney injury in patients with essential hypertension.Methods:180patients with essential hypertension from December 2018 to December 2019 were included in this study.General clinical data and medical history were collected.Height,weight,systolic pressure(SBP),and diastolic blood pressure(DBP)were measured,then body mass index(BMI)was calculated.Serum creatinine(Scr),fasting plasma glucose(FPG),blood lipid,blood electrolyte,24-hours urinary potassium ect were detected.According to the simplified MDRD formula,glomerular filtration rate of each patient was calculated and then divided into into two groups:93 cases in the normal group(eGFR≥90ml/min·1.73m~2)and 87 cases in abnormal group(45≤eGFR≤89ml/min·1.73m~2).To confirm the difference of general clinical data,biochemical indexes and 24-hour urinary potassium between the two groups.Then single-factor correlation analysis and multiple factors gradually Logistic regression analysis were used to confir m the correlation between 24-hour urinary potassium ect and kidney injury.Results:1.Comparison of general clinical data,biochemical indexes and 24-hour urinary potassium ect between the two groupsThere is no statistical difference on two groups in the age,sex,BMI,disease course,hypertension grade,SBP,DBP,blood potassium,blood sodium,blood sodium/potassium,FPG,triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),uric acid(UA),blood urea nitrogen(BUN)and24-hour urinary sodium(P>0.05);compared with the normal group,abnormal group,s serum creatinine,24-hour urinary protein and 24-hour urinary sodium/potassium levels goes up and24-hour urinary potassium levels goes down(P<0.05).2.Single-factor correlation analysis of 24-hour urinary potassium and other indicators with eGFRTaking eGFR as the dependent variable,24-hour urinary potassium and other indicators as the independent variables,the result shows that 24-hour urinary potassium is positively correlated with eGFR(r=0.534,P<0.05),24-hour urinary sodium/potassium、24-hour urinary protein and serum creatinine are negatively correlated with eGFR(r=-0.364,r=-0.402,r=-0.739,P<0.05);there is no statistical correlation among BMI,course of disease,systolic blood pressure,diastolic blood pressure,blood potassium,blood sodium,blood sodium/potassium,TG,TC,HDL-C,LDL-C,UA,BUN,FPG,24-hour urinary sodium and eGFR(P>0.05).3.Multiple factors correlation analysis between 24-hour urinary potassium and other indicators and kidney injuryTaking whether merge kidney injury as dependent variable(yes=1,no=0),age、sex、SBP、DBP、serum creatinine,24-hour urinary sodium、24-hour urinary potassium,24-hour urinary sodium/potassium,24-hour urinary protein as the independent variables,proceeding multiple factors gradually Logistic regression analysis shows that 24-hour urinary potassium is negatively correlated with kidney injury.24-hour urinary potassium is negatively correlated with kidney injury;serum creatinine is positively correlated with kidney injury.ConclusionIn the patients with essential hypertension in this study,24-hour urinary potassium is positively correlated with eGFR,24-hour urinary potassium is negatively correlated with kidney injury. |
