Comparison Of The Spot Urine And 24-hour Urine Collection Method In Evaluating 24-hour Sodium And Potassium Excretion In Patients With Hypertension

0bjective: To explore the comparison of the spot urine and 24 h urine collection method in evaluating 24 h sodium and potassium excretion in patients with hypertension.Methods: Between February 2017 and January 2018,264 patients with hypertension in hypertension department of The First Affiliated Hospital Of Xinjiang Medical University were enrolled in the study.24 h urine specimens and morning fasting spot urine specimens were collected for detecting urinary sodium,potassium and creatinine.The Tanka,Kawasaki and INTERSALT formulas were used to estimate the 24 h urinary sodium and potassium excretion.The paired sample rank sum test was used to compare the difference between the estimated value and the measured value.Using Spearman correlation coefficient to evaluate the relationship between 24 h urinary sodium and potassium excretion estimated by each formula and 24 h of urinary sodium and potassium excretion.Results: The 24 h urinary sodium value estimated by Tanaka formula(167.99 mmol/d)was higher than that estimated by actual 24 h urinary sodium value(157.73 mmol/d),with no significant difference(z=-0.23,P>0.05);the 24 h urinary sodium value estimated by Kawasaki formula(217.66 mmol/d)was also higher than that estimated by actual 24 h urinary sodium value(157.73 mmol/d),with significant difference(z=-8.81,P<0.05);and the 24 h urinary sodium value estimated by INTERSALT formula(154.71mmol/d)was lower than the actual 24 h urinary sodium value(157.73 mmol/d),and the difference was statistically significant((z=-3.53,P<0.05).The correlation coefficients between the estimated values of Tanaka,Kawasaki and INTERSALT formula and the actual 24 h urine sodium value were 0.68,0.55,0.58,respectively,P<0.01;Tanaka formula estimated potassium excretion value(39.51mmol/d)is lower than the actual measured value(42.90 mmol/d),the difference was statistically significant(z=-3.47,P<0.05),the correlation coefficient was 0.50,P<0.01.Conclusion: In patients with hypertension,the 24 h urine sodium value estimated by the Tanaka formula is not different from the actual 24 h urine sodium value,and the correlation is high.The 24 h sodium and sodium excretion estimated by the Kawasaki and INTERSALT formulas are different from the actual measured values.Underestimation and overestimation,the correlation is low,there is an underestimation between the 24 h urinary potassium excretion estimated by the Tanaka formula method and the actual measured value,and the correlation is low.Therefore,the Tanaka formula can be used to estimate the 24 h urinary sodium excretion of hypertensive patients,and the 24-hour urinary potassium excretion of hypertensive patients cannot be estimated by point urine method.