Correlative Study On The Level Of Serum Cystatin-C In Different Severity Of Patients With Stable Chronic Obstructive Pulmonary Disease

Objective:To observe change and the correlation of serum cystatin C（Cys-C）levels of the stability of stable chronic obstructive pulmonary disease（COPD）patients with different limited airflow and the severity of disease.Methods:A total of 94 COPD patients of in shangxi dayi hospital from January 2016 to December were followed up as COPD group;31 healthy subjects in the hospital physical examination center were selected as healthy control group.Pulmonary function tests,serum cystatin C and creatinine（Cr）levels were measured respectively,meanwhile,Calculated glomerular filtration rate.According to the estimated percentage of pulmonary function FEV1,the patients with COPD were divided into four different subgroups:GOLD1,2,3 and4stages;According to the history of acute exacerbation number and COPD assessment test,the patients with COPD were divided into four different subgroups;A,B,C and D.Results:1.The serum Cys-C level in patients with stable COPD was higher than those in healthy controls（P<0.05）.2.There were significant differences in the serum Cys-C among stable COPD patients of GOLD1,2,3 and 4stage（P<0.01）,the serum Cys-C levels in GOLD4stage were higher than GOLD1,2,3 stages.3.There were significant differences in the serum Cys-C among stable COPD patients of A,B,C and D subgroup（P<0.01）,the serum Cys-C levels in D subgroup were higher than A,B subgroups,the serum Cys-C levels in C subgroup were higher than A subgroup.4.The serum Cys-C levels were positive correlated with CRP（P<0.01）and significantly negative correlated with FEV_{1（）P<0.01},and GFR（P<0.01）.Conclusions:COPD patients serum Cys-C level is higher,and increased with COPD disease severity.The serum Cys-C level may become biomarkers for the assessment of severity in patients with COPD.